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Correct Answer - C
Answer- C. Membrane defect
* Among the defects in hexose monophosphate shunt, the most
common is G6PD deficiency.
* G6PD gene is located on the X chromosome and its deficiency is,
therefore, a sex (X)-linked trait affecting males, while the females
are carriers and are asymptomatic.
* PATHOGENESIS: Normally, red blood cells are well protected
against oxidant stress because of an adequate generation of
reduced glutathione via the hexose monophosphate shunt.
* Individuals with inherited deficiency of G6PD, an enzyme required for hexosemonophosphate shunt for glucose metabolism, fail to develop adequate levels of reduced glutathione in their red cells.
* The clinical manifestations are those of acute hemolytic anemia
within hours of exposure to oxidant stress.
* The hemolysis is, however, self-limiting even if the exposure to the oxidant is continued since it affects the older red cells only
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Not a feature of G-6PD deficiency?#PYQ#FMGE#NEETPG#INICETAnonymous voting
- A.Intra vascular hemolysis
- B.Oxidative stress
- C.membrane defect
- D.Bite cell
π 17π 4π 4β€ 1
Correct Answer - D
Answer- D. 2
A normal CD4/CD8 ratio is 2.0, with CD4 lymphocytes equal to or
greater than 400/mm3 and CD8 lymphocytes equal to 200 to
800/mm3.
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Normal value of CD4:CD8 ratio is -#PYQ#FMGE#NEETPG#INICETAnonymous voting
- A.0.1
- B.0.5
- C.1
- D.2
π 32
Correct Answer - B
Answer- B. Squamous cell carcinoma
-MYC and RB - small cell cancer
RAS and p16 - non-small cell cancer
p53 - both small and non-small cell, but highest in squamous cell
carcinoma
K-RAS βadenocarcinoma
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Deficiency of p53 mutation is maximum
in which lung carcinoma?#PYQ#FMGE#NEETPG#INICETAnonymous voting
- A.Small cell carcinoma
- B.Sqamous cell carcinoma
- C.Adenocarcinlma
- D.Lymphoma
π 21π₯ 8β€ 7
Correct Answer - B
Answer- B. Bronchi and bronchioles
-Allergic bronchopulmonary aspergillosis (ABPA) is a condition
characterized by a hypersensitivity response to the Aspergillus (most
commonly Aspergillus fumigatus).
-An allergic bronchopulmonary aspergillosis is a form of lung disease that occurs in some people who are allergic to Aspergillus.
-With ABPA, this allergic reaction causes the immune system to
overreact to Aspergillus leading to lung inflammation.
-ABPA causes bronchospasm (tightening of airway muscles) and
mucus buildup resulting in coughing, breathing difficulty and airway obstruction.
*it also causes airway inflammation, leading to bronchiectasisβa
condition marked by abnormal dilation of the bronchi and
bronchioles.
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In allergic bronchopulmonary
aspergillosis, the location of lesions is
#PYQ#FMGE#NEETPG#INICETAnonymous voting
- A.Pleura
- B.Bronchi and bronchioles
- C.Alveoli
- D.All of the above
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