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*Dear Doctor,* I would highly appreciate your participation in our research study titled: *“Effectiveness and Diagnostic Reliability of Tele-dermatology in Primary Care among Family Physicians in Riyadh, Saudi Arabia.”* The survey takes approximately 3 minutes to complete and aims to assess Family physicians’ experiences with virtual dermatology consultations. Participation is voluntary, and all responses are anonymous and confidential. *survey link:* https://forms.gle/PJVigwYeqcdas1Bx6 *Thank you for your valuable time and contribution.*

For more than 60 years, Metformin has been prescribed to hundreds of millions of people with Type 2 Diabetes. While clinicians knew it was effective, the exact mechanism behind its action remained only partially understood. Researchers at Baylor College of Medicine have now uncovered a crucial aspect of this mystery. Their findings, published in Science Advances, suggest that metformin works directly through the brain, revealing a previously unidentified mechanism. The study focuses on a protein called Rap1 located in the Ventromedial Hypothalamus, a key control center for whole-body metabolism. When metformin reaches the VMH, it switches off Rap1, which activates a group of neurons known as SF1 neurons. These neurons then signal the body to reduce blood glucose levels. In experiments, mice genetically engineered without Rap1 in this brain region showed a striking result: metformin stopped working entirely, even when the mice were on a high-fat diet. Interestingly, other diabetes treatments, such as insulin and GLP-1 receptor agonists, continued to function normally, suggesting that this brain pathway is unique to metformin. Another remarkable finding was the brain’s extreme sensitivity to the drug. While the liver and intestines require relatively high drug concentrations to respond, the brain reacted to doses thousands of times lower than typical oral doses. These insights reshape decades of understanding. Metformin may not simply act through the liver or gut as traditionally believed, it has likely been influencing the brain’s metabolic control systems all along. Researchers are now exploring whether this Rap1 brain pathway could also explain metformin’s other reported benefits, including potential effects on brain aging and longevity. Human studies are still required to confirm these mechanisms, but the discovery opens the door to more precise and targeted diabetes therapies in the future. 📄 Reference: Lin et al. (2025). Low-dose metformin requires brain Rap1 for its antidiabetic action. Science Advances.

A systematic review is not about reading everything. It is about reading with intention, and with responsibility toward existing evidence. The paper I’m sharing today is a firm reminder of that. Several principles in the paper are worth slowing down for. A systematic review answers a clearly defined research question, not a vague topic. Clarity at the question level determines every decision that follows, from search strategy to synthesis. Transparent search strategies are essential. They allow others to understand, replicate, and trust your process. Transparency is not an administrative detail. It is part of the argument. Inclusion and exclusion criteria protect against bias. They do not limit creativity. They prevent convenience from masquerading as judgment. Quality appraisal matters as much as quantity. The number of studies included means little if their methodological strength is not evaluated carefully. Synthesis is more than summarizing. It requires interpretation, structure, and judgment. This is where insight is earned, not assumed. Reporting standards strengthen credibility. They signal care, discipline, and respect for the reader, and for the field itself.

HTA is a multidisciplinary process that uses explicit methods to determine the value of a health technology at different points in its lifecycle. The purpose is to inform decision making in order to promote an equitable, efficient, and high-quality health system.

شكرًا لمشاركتك في هذه الدراسة البحثية التي تهدف إلى تقييم الالتزام بفحص سرطان الثدي وتحديد العوائق التي قد تحول دون إجرائه بين عامة السكان في المملكة العربية السعودية. نؤكد أن جميع المعلومات ستُستخدم لأغراض البحث فقط. https://forms.gle/bcEY16V1TutYMXHeA ارجوا نشره لكل المضافين عندكم ربي يكتب اجركم جميعا

هذه الاستبانة للدكتور محمد ابو طالب صيدلي استشاري في مستشفى الملك فهد بجازان ويسعده مشاركاتكم السلام عليكم ورحمة الله وبركاته يسعدني رأيكم لإثراء نموذج الرعاية الصحية... وفقكم الله https://forms.gle/kxppf4EBR3k4bwyT8

New treatment for fibromyalgia..

في بيئة الأعمال، نسمع هذه المصطلحات كثيرًا، وأحيانًا تُستخدم بشكل متداخل، لكن الحقيقة أن لكل منها دور مختلف: 1️⃣ الحوكمة (Governance) الإطار العام الذي يحدد كيف تُدار المؤسسة وتُتخذ القرارات، لضمان الشفافية، المساءلة، وحماية حقوق المساهمين وأصحاب المصلحة. 2️⃣ الالتزام (Compliance) التأكد من أن المؤسسة تلتزم بالقوانين، الأنظمة، والمعايير المحلية والدولية، وتفادي المخاطر القانونية والتنظيمية. 3️⃣ المراجعة الداخلية (Internal Audit) تقييم مستقل وموضوعي لمدى كفاءة وفعالية الضوابط الداخلية، وإدارة المخاطر، وعمليات المؤسسة. 💡 الفارق الجوهري: • الحوكمة هي الخريطة. • الالتزام هو التأكد من السير وفق القوانين. • المراجعة الداخلية هي الفحص الدوري للتأكد أن كل شيء يسير كما يجب. في النهاية… التكامل بين الثلاثة هو ما يصنع بيئة عمل قوية، شفافة، ومستدامة منقوول.

قنوات بيكسل عربي انستجرام https://www.instagram.com/pixelarabi?igsh=Mzc3cXduNjhodDV5 تيك توك https://www.tiktok.com/@pixelarabi?_t=ZS-8xGHAnwrPNp&_r=1 يوتيوب https://youtube.com/@pixelarabi?si=bnfvL2llupP1NZKa تويتر (x) https://x.com/pixelarabi_?s=21&t=sns402KGpehGcnJrAgJR6Q Bay me a coffee coff.ee/pixelarabi بهمنا الدعم والمشاركة ورأيكم واقتراحاتكم ♥️

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