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شرح مادة الصيدلة السريرية clinical pharmacology 🧑🏻⚕️ معرف التلي: mohammedsalim10 Instagram: _a1mh
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A 35-years old male patient with tuberculosis, few months after his recovery this patient developed weakness, additional weight loss, salt craving, headaches, memory impairment, depression, and postural dizziness. Prednisolone tab 5 mg and fludrocortisone acetate 0.1 mg tab daily were prescribed to control his symptoms. Recently this patient exposed to car accident resulted in massive blood loss and head injury.
What is the recommended management plan regarding his condition?
a- Double his oral daily doses of both Prednisolone and Fludrocortisone with using proper fluid therapy until stabilized.
b- Double his daily oral Prednisolone dose and switch to Deoxycorticosterone trimethylacetate injection with proper fluid therapy until stabilized.
c- Switch to oral Hydrocortisone 25 mg with proper fluid therapy and omit fludrocortisone.
d-Switch to Hydrocortisone 100 mg IV by rapid infusion, followed by 200 mg over 24 hours as a continuous infusion with proper fluid therapy until stabilized.
e-Switch to oral Hydrocortisone 50 mg every 6-8 hours with proper fluid therapy until stabilized and omit fludrocortisone.
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M.S, a 55-year-old fomale on Etomidate prepared to Transsphenoidal resection of the pituitary tumor for her Cushing disease. Recently she developed an emergent medical condition necessities addition of an oral hypoglycemic drug to her regimen and this operation not possible to be performed.
Which medication is most optimal to be used at this time to control patient symptoms regarding the elevated cortisol level?
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An adult woman patient with classic Cushing's disease (caused by a pituitary adenoma) referred to surgery, Laparoscopic adrenalectomy is her current treatment according to her physician mostly because?
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How should patients with Addison's disease using corticosteroid replacement manage their doses during stressful situations?
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Pasireotide is approved for use in Cushing disease primarily because:
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Adrenal insufficiency is caused by multiple etiologies. The most common cause of secondary adrenal insufficiency in countries like Iraq and Egypt is
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27-year-old woman comes to endocrinologist because she has had suffer from hair on her face, chest, and back as well as irregular menses for the past 10 months. She says she also has had easy bruising with poor wound healing during this time. Diagnosis of Cushing syndrome is confirmed by laboratory tests. Which one of the following drugs is most appropriate for this patient?
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Adrenal insufficiency produced by Autoimmune dysfunction or drugs, which drug was reported to induce secondary adrenal insufficiency?
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Mitotane is a cytotoxic drug. All the followings are true about Mitotane EXCEPT
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Hyperaldosteronism can cause several disturbances. One of the following is not a Clinical Presentation of hyperaldosteronism:
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50-year-old man with advanced tuberculosis has developed signs of severe acute adrenal insufficiency. The patient should be treated immediately with a combination of
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The pharmacological therapy of Cushing's Syndrome involves different agents. A glucocorticoid-receptor blocking agent used as part of the pharmacologic therapy of Cushing's syndrome is:
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Regarding endogenous Cushing's syndrome accompanied by type 2 DM, the best treatment is.
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Lifelong glucocorticoid replacement therapy may be necessary for patients with adrenal insufficiency. Hydrocortisone is often prescribed because it has the following characteristic EXCEPT:
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L.S is 35 years old male, he was presented with the following sign and symptoms: muscle weakness, fatigue, paresthesias, headache, polydipsia, and nocturnal polyuria. He also had elevated blood pressure and tetany. Blood pressure: 160/100 mmHg Serum potassium: 1.2 mEq/i normal value (3.5-5 mg/l) Aldosterone hormone level: elevated. What is the first line treatment for this case?
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Cushing Syndrome has several clinical presentations. One of the followings is not a clinical presentation of Cushing Syndrome
