Pathology - Malek

“What is the differential diagnosis (DDx) for the bone marrow aspirate findings shown in the image?”

“What is the differential diagnosis (DDx) for the bone marrow aspirate findings shown in the image?”

Post-transfusion purpura (PTP) is caused by alloantibodies against platelet antigens and can lead to severe thrombocytopenia.

Transfusion-related circulatory overload (TACO) is a rare condition and does not require careful monitoring.

The most common cause of transfusion-related deaths is bacterial contamination.

Febrile reactions due to WBC and platelet antigens usually occur within 5 minutes of starting the transfusion.

Delayed hemolytic transfusion reactions usually manifest 7-10 days after transfusion.

The incidence of transfusion reactions is about 20-25%

ABO incompatibility is the most common cause of immediate hemolytic transfusion reactions (HTR).

Endotoxic shock is caused by gram-positive bacteria

Most cases of septic shock are caused by gram-negative bacteria .

Most cases of septic shock are caused by gram-negative bacteria .