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A 55-year-old female patient with breast cancer is receiving doxorubicin and cyclophosphamide. After 4 cycles, echocardiography shows LVEF 35% (baseline 65%). What is the most appropriate next step?
A 65-year-old male patient with Parkinson's disease on carbidopa/levodopa 25/100 mg QID develops severe peak-dose dyskinesias and wearing-off periods. What is the most appropriate adjunctive therapy?
A 32-year-old pregnant woman at 36 weeks gestation presents with blood pressure of 180/110 mmHg, proteinuria 6 g/24h, severe epigastric pain, and blurred vision.Platelet count is 65,000/μL. AST is 200 U/L.What is the most appropriate immediate management?
A 50-year-old male patient with chronic hepatitis B on tenofovir disoproxil fumarate develops eGFR decline from 95 to 50 mL/min and hypophosphatemia. What is the most appropriate management?
Which class of antibodies is primarily involved in allergic reactions?
According to the Ethiopian inventory control system, what method is used?
A patient has a brassy cough, bloody sputum, weight loss, fever, and night sweats. What is this condition most likely to be?
What is the most likely physical instability seen in a propofol emulsion when oil droplets aggregate at the surface?
A compounding pharmacist prepared hydrophilic petrolatum base by melting stearyl alcohol and white wax on a steam bath. What is the most likely unit operation used?
The process of "Categorizing the request" is most associated with which pharmacy domain?
A patient with asthma is prescribed a short-acting beta-agonist for rescue. Which of the following is an example of a short-acting beta-agonist?
Q- Which one of the following medications is the best initial treatment for a case of heart failure with normal systolic function and preserved ejection fraction?
A-Digoxin
B-Furosemide
C-Metoprolol
D-Spironolactone
@PharmacyRxplus
@PharmacyRxplus
1. A 72-year-old male patient with heart failure with reduced ejection fraction
(LVEF 30%) is on sacubitril/valsartan 97/103 mg BID, bisoprolol 10 mg daily,
spironolactone 25 mg daily, and furosemide 40 mg BID. His blood pressure is
88/50 mmHg, heart rate 50 bpm, potassium 5.8 mEq/L, creatinine 1.8 mg/dL. He
reports worsening dyspnea and fatigue. What is the most appropriate next
intervention?
A. Increase sacubitril/valsartan to 194/206 mg BID
B. Reduce spironolactone to 12.5 mg daily and reduce bisoprolol to 7.5 mg daily
C. Add digoxin 0.125 mg daily
D. Increase furosemide to 80 mg BID
