PythonHub

Seapie – a Python debugger where breakpoints drop into a REPL https://github.com/hirsimaki-markus/seapie

Axis – A systems programming language with Python syntax https://github.com/AGDNoob/axis-lang

davila7 / claude-code-templates CLI tool for configuring and monitoring Claude Code https://github.com/davila7/claude-code-templates

Jsonic – Python JSON serialization that works https://medium.com/dev-genius/jsonic-python-serialization-that-just-works-3b38d07c426d

I built a wrapper to get unlimited free access to GPT-4o, Gemini 2.5, and Llama 3 (16k+ reqs/day) https://www.reddit.com/r/Python/comments/1q87ngh/i_built_a_wrapper_to_get_unlimited_free_access_to/

I Made a Classic Refactoring Mistake Arjan addresses mistakes in his prior video's refactoring of a messy order approval function, identifying three logic errors via failing tests. He discusses refactoring pitfalls like incomplete tests (86% coverage despite bugs), tricky and/or conditions, data structures, and the lack of a true "ground truth" in business logic. https://www.youtube.com/watch?v=b6RnBKvQ40o

Anthropic has made a large contribution to the Python Software Foundation https://discuss.python.org/t/anthropic-has-made-a-large-contribution-to-the-python-software-foundation-and-open-source-security/105694

Pyinfra: Turns Python code into shell commands and runs them on your servers https://github.com/pyinfra-dev/pyinfra

FastScheduler – Decorator-first Python task scheduler, async support https://github.com/MichielMe/fastscheduler

Python Hub Weekly Digest for 2026-01-11 https://pythonhub.dev/digest/2026-01-11/

MyTorch – Minimalist autograd in 450 lines of Python https://github.com/obround/mytorch

SleepFM A multimodal sleep foundation model that can predict 130 diseases from 1 night of sleep. https://github.com/zou-group/sleepfm-clinical

PennyLane PennyLane is a cross-platform Python library for quantum computing, quantum machine learning, and quantum chemistry. Built by researchers, for research. https://github.com/PennyLaneAI/pennylane

WebAssembly as a Python Extension Platform https://nullprogram.com/blog/2026/01/01/

Recent optimizations in Python's Reference Counting CPython 3.14+ introduced LOADFASTBORROW, a bytecode optimization that skips reference count increments when loading local variables in hot loops, using static lifetime analysis to ensure safety. This reduces memory management overhead in performance-critical code like tight loops, mimicking Rust-style borrowing while preserving Python's reference counting model, with further JIT optimi... https://rushter.com/blog/python-refcount/

Unit testing your code’s performance, part 1: Big-O scaling Your software’s speed needs some form of testing; big-O scaling is a good starting point. https://pythonspeed.com/articles/big-o-tests/

awesome-agentic-patterns A curated catalogue of awesome agentic AI patterns. https://github.com/nibzard/awesome-agentic-patterns

How uv got so fast uv's speed comes from engineering decisions, not just Rust. Static metadata, dropping legacy formats, and standards that didn't exist five years ago. https://nesbitt.io/2025/12/26/how-uv-got-so-fast.html

LLMRouter An Open-Source Library for LLM Routing. https://github.com/ulab-uiuc/LLMRouter

Sandboxing Untrusted Python https://gist.github.com/mavdol/2c68acb408686f1e038bf89e5705b28c