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Repost from قناة اسئلة + تسليكات المرحله الرابعه
1.drug was low volume of distribution is likely to be found
A. in circulatory system
B. in CNS
C. extravascular system
D. in lipid
2.Most of drug absorbed across cell membrane of the gut fibrosis
A. carrier mediated transport
B. diffusion through aqueous pores
C. diffuse through lipid
D. phenocytosis
3.factor cannot directly affect on rate of metabolism
A. Genetic mutation
B. Age
C. route of adminstration
d. Disease status
4.Drug exhibit zero order kinetic
A. rate of Elimination
B. half life constant
C. drug clearance is constant
D. plasma drugs concentration is constant
5.which of the following increase rate of drug absorption of gut
A. oral bioavailability
B. volume of distribution
C. peak plasma drug concentrations
D. Duration of action
6.drug decrease in which the following
A. enzymatic interaction
B. renal failure
C.liver failure
D. cardiovascular disease
7.which type of drug have high volume of distribution
A. water soluble
B. lipid soluble
C. high molecular weight
8.concerning the affect of pH on urine excretion of drug
A. urinary alkalinization accelerate excretion of weak acid
9. correct sequence of pharmacokinetic drug
A. absorption, distribution, metabolism, and excretion
10.which are the two rate determing step of drug absorption when giver orally
A. disintegration and deaggregation
B. disintegration and dissolution
C. dissolution and permation through membrane
D. permation through membrane and disintegration
11. hepatic cytocrome p450 drug metabolizing enzyme are primarily found in
A. plasma membrane
B. cytoplasm
C. smooth endoplasmic reticulam
D. mitochondria
12. what is measure different between facilitated diffusion and passive diffusion
A. carrier mediated transport
B. inhibition by metabolic
13. which form of drug has greater solubility
A. anhydrous
B. hydrate
C. crystalized
C. monohydrous
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