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Benztropine
#Anticholinergic #Antiparkinsonian #EPS #dailydose
Mechanism:
Blocks muscarinic (M1) receptors in the CNS → restores the dopamine–acetylcholine balance in the striatum.
🩺 Uses:
Parkinsonism
Drug-induced extrapyramidal symptoms (EPS), especially acute dystonia
💊 Administration & Dose:
Route: Oral, IM, or IV
Parkinsonism: 0.5–1 mg once daily, gradually increased; usual 1–2 mg/day
Drug-induced EPS: 1–2 mg once or twice daily
Interactions:
Other anticholinergics → ↑ anticholinergic effects
Antihistamines/TCAs → ↑ dry mouth, constipation, urinary retention
Antipsychotics → may mask/treat EPS
⚠️ Adverse Effects:
Dry mouth
Blurred vision
Constipation
Urinary retention
Tachycardia
Confusion
⛔ Precautions:
Use cautiously in elderly patients and those with glaucoma or urinary retention.
🚫 Avoid if:
Narrow-angle glaucoma
GI obstruction
Urinary retention
✅ Antimuscarinic used for drug-induced parkinsonism and acute dystonia.
‼️ Not recommended for tardive dyskinesia; it may worsen it.
‼️ Safe use of benztropine during pregnancy has not been established
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👁🗨#Kaffaltiin Yeroo Idileen Alaa (Night Duty) Ogeessota Fayyaa Adoolessa 2018 irraa kaasee miindaa haaraan akka kaffalamu murtoon darbeera.
Murtoon kun hojii yeroo Idileen Alaa tajaajila kennan jajjabeessuuf, hojii isaanii kabajuu fi fayyadamummaa ogeessota fayyaa cimsuuf kan kaayyeffate yoo ta'uu Raawwiin kaffaltii kun qajeelfamaa fi sirna raawwii mootummaa irratti hundaa'uun ni adeemsifama.
Baga gammaddan!!
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Repost from N/a
Contraindicated antimicrobial drugs in pregnancy! 🚫💊
SAFe Children Take Really Good Care 👶🏨
S = sulfonamides 💊
A = aminoglycosides 🧪
F = fluoroquinolones 🦠
C = clarithromycin 🩺
T = tetracyclines 🦷
R = ribavirin (antiviral) 🦠
G = griseofulvin (antifungal) 🍄
C = chloramphenicol 🧬
#Mnemonic
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28. If the selling price of the medicines is 120 birr at dispensary, with a profit margin of 20%, what is the cost of the medicines(Selling price =cost + profit margin)?
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19. What is the boxed warning associated with febuxostat?
a. Hepatic failure
b. Increased risk of cardiovascular death compared to allopurinol
c. Anaphylaxis
d. Hemolytic anemia
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18. Which genetic test should be performed before starting allopurinol in patients of Asian or African American descent?
a. CYP2D6 genotyping
b. G6PD screening
c. HLA-B*5801 testing
d. TPMT genotyping
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13. What is the first-line urate-lowering therapy for gout prophylaxis?
a. Febuxostat
b. Probenecid
c. Allopurinol
d. Pegloticase
