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A 28-year-old G2P1 woman of Southeast Asian origin is at 15 weeks gestation. Her first child has homozygous beta-thalassemia major requiring regular blood transfusions. Both parents are known carriers of beta-thalassemia trait. She has declined preimplantation genetic diagnosis. Today, an ultrasound shows a normal fetal anatomy but a slightly increased nuchal translucency (3.2 mm) and cardiomegaly. The mother wants definitive prenatal diagnosis for the current pregnancy.
What is the most appropriate investigation ?
· A) Maternal serum alpha-fetoprotein (MSAFP) screening
· B) Cell-free fetal DNA from maternal blood (non-invasive prenatal testing, NIPT)
· C) Chorionic villus sampling (CVS)
· D) Amniocentesis
· E) Fetal ultrasound at 20 weeks for hydrops
A 30-year-old G2P1 woman with Rh isoimmunization (anti-D titer 1:128) is at 27 weeks of gestation. Her first child had severe hemolytic disease requiring exchange transfusion. Today, ultrasound shows MCA-PSV = 1.7 MoM (above 1.5). No fetal hydrops is seen yet. The biophysical profile is normal. The mother asks about next steps to assess fetal anemia.
What is the most appropriate next investigation ?
A) Middle cerebral artery peak systolic velocity (MCA-PSV) Doppler
· B) Amniocentesis for bilirubin level
· C) Cordocentesis (percutaneous umbilical blood sampling)
· D) Non-stress test (NST) and biophysical profile (BPP)
· E) Fetal echocardiography
A 29-year-old G1P0 at 38 weeks of gestation with diet-controlled gestational diabetes presents to labor and delivery triage reporting decreased fetal movements over the past 12 hours. Her vital signs are normal, and the abdominal examination shows a fundal height consistent with dates. A bedside non‑stress test (NST) is performed and is non‑reactive after 40 minutes, with no accelerations but minimal variability. What is the most appropriate next step?
يعني اذا عده شغله وحده من الجدول الاول او شغلتين وفوك من الجدول الثاني لازم تاخذ اسبرين
Regarding physiological changes in pregnancy , which one is correct
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