Group( D )

......This form results from the deletion or inactivation of three alpha globin genes,مهمه

.......characterized by mild anemia and low red blood cell indicesمهمه

is more common in Southeast Asia,

.......This form is usually caused by the deletion of two alpha genes on one chromosome 16 مهمه

.........There are two alpha genes located on each chromosome 16.مهمه

Thalassemia is due to decreased production of two or more globin chains.

alpha-globin genes on chromosome 16

of the ........gene on chromosome 11.

....... It is caused by mutations or deletions of the Hb genes?مهمه

There are over 200 mutations identified as the culprits for causing thalassemias.

......... is autosomal recessive, which means both the parents must be affected with or carriers for the disease

Megaloblastic anemia is diagnosed through physical exam and other tests?

...... detect the antibodies toward intrinsic factor or the cells that produce it?

..........to measure of vitamin B12, methylmalonic acid (MMA) or homocysteine levels ?

........ may be necessary if the diagnosis is unclear. مهمه

........ is one of the earliest, most sensitive and specific signs of megaloblastic anemia?

........to be pathognomonic of the. prnicious anemia disease.مهمه

Nerve cells and blood cells need vitamin B12 to function properly. مهمه