قسم الـعملي "LAB Section"_الدفعة السادسة

#Microscopic #Diagnosis 👉🏻 Medullary carcinoma #The_blue_arrow hyaline material الذي تظهر باللون الوردي #The_red_arrow Amyloid NOTES • The medullary carcinoma is Neuroendocrine tumor derived from C cells (formerly called parafollicular cells)  • Painless • can be sporadic or familial. The familial kind are associated with multiple endocrine neoplasia syndrome.

#Microscopic #Diagnosis 👉🏻 Papillary carcinoma #The_blue_arrows Nucler inclusion #The_black_arrows Vascular nucleus

#Microscopic #Diagnosis 👉🏻  Papillary carcinoma #The_blue_arrows Overlapping nuclei #The_black_arrows Groove nuclei #The_red_arrows Optical clear nuclei ( ground glass nuclei)

#Microscopic #Diagnosis 👉🏻  Papillary carcinoma #The_white_arrow Psammoma body #The_green_arrows Optical clear nuclei ( ground glass nuclei) #The_blue_arrows Papillae #The_black_arrows Papillae by transfert section #The_features Nuclear features - Change of nuclear size and shape • nuclear enlargement, elongation • Nuclear overlapping:  the nuclei are so crowded that they look like they are sitting on one another • Ground glass nuclei : it means the chromatin is finely dispersed and optically clear. This appearance is also known as “Orphan Annie Eye”  • groove nuclei are formed due to folding of  the unessential nuclear membrane • nuclear inclusions • Vascular Nuclei - Nuclear membrane irregular Other features - randomly oriented papillae with fibrovascular cores - Psammoma body in the fibrovascular cores

#Gross #Diagnosis 👉🏻  Papillary carcinoma #The_black_arrow papillary projections of the tumor #The_white_arrows Tumor tissue #The_blue_arrow Calcification #The_green_arrow Normal thyroid

#Gross #Diagnosis 👉🏻  Papillary carcinoma #The_blue_arrow Colloid #The_black_arrow Normal thyroid #The_white_arrow papillary projections of the tumor #The_white_star Tumor tissue

#Gross #Diagnosis 👉🏻  Papillary carcinoma #The_blue_arrows Normal thyroid #The_black_arrows Tumor tissue #The_red_arrow Calcification (Psammoma body) #The_yellow_arrows Tumor tissue هنا عامله infiltrative #The_features - The tumor is usually solid - grey white in color - papillary projections - sometimes it can be multifocal - encapsulated or infiltrative - calcification (appear white in color)

#Microscopic #Diagnosis 👉🏻 follicular thyroid neoplasm #The_black_arrow Normal follicles #The_red_area Capsule #The_white_arrow Neoplasm (adenoma)

#Microscopic #Diagnosis 👉🏻 follicular thyroid neoplasm #The_black_arrow Normal follicles #The_red_area Capsule #The_white_arrow Neoplasm (adenoma) #The_features - well differentiation - an encapsulated round neoplasm - The tumor is composed of cloclosely packed follicles

#Gross #Diagnosis 👉🏻 follicular thyroid neoplasm ( follicular adenoma )

#Gross #Diagnosis 👉🏻 follicular thyroid neoplasm (follicular adenoma) #The_white_arrow Normal thyroid #The_black_arrow Capsule #The_blue_star Neoplasm (adenoma) #The_features - an encapsulated round neoplasm with a uniform (solitary) nodule. - bright brown appearance, surrounded by a rim of normal thyroid NOTES • Cause pressure symptoms • Painless • Cause hyperthyroidism

#Microscopic #Diagnosis 👉🏻 graves diseases #The_black_area  lymphoid follicle #The_blue_arrows papillary infoldings #The_brown_arrows follicular cells appear columnar #The_yellow_arrows Scalloping or vacuoles

#Microscopic #Diagnosis 👉🏻 graves diseases #The_black_area  lymphoid follicle #The_blue_arrows papillary infoldings #The_features - Tall follicular cells (tall columnar epithelium cells) with papillae usually lacking fibrovascular cores بسبب انه الخلايا حصل لها hyperplasia - Nuclei are round, often basally located, rarely overlap - Scalloping of colloid , or vacuoles due to follicular cells eat colloid for the production of hormones

#Microscopic #Diagnosis 👉🏻 Colloid goiter ( simple goiter/diffuse nontoxic goiter) #The_black_area Follicle  #The_features The follicles enlarged and filled by abundant colloid , with Flattened follicular epithelial lining

#Gross   #Diagnosis 👉🏻  Colloid goiter -thyroid with colloid cysts- ( simple goiter/diffuse nontoxic goiter) #The_white_arrow Large colloid cyst #The_black_arrow Small colloid cyst #The_features Diffuse enlargement gland with brownish cysts, cut surface is brown (colloid)

#Microscopic #Diagnosis 👉🏻  Multinodular goiters #The_white_area Follicles #The_black_area Fibrosis septa  #The_blue_arrows Hemorrhage

#Microscopic #Diagnosis 👉🏻  Multinodular goiters #The_blue_arrows  Colloid #The_black_area Fibrosis septa  و Nodule هي يلي محوطه ب septa كامل #The_features - Multinodular are variable in size and shape , separate by septa - The single nodule composed of multiple thyroid follicles that are Dilated by Colloid with flattened to hyperplastic epithelium cells ✓ The follicles are variable in size , separated by fibrous stroma

#Gross   #Diagnosis 👉🏻  Multinodular goiters #The_white_area Nodules #The_black_arrow Fibrosis Septa #The_blue_stars colloid #The_yellow_arrows Hemorrhage #The_features cut surface shows multinodular separated by fibrosis septa , hemorrhagic , brown colloid with focal calcification

#Gross   #Diagnosis 👉🏻  Multinodular goiters (simple goiter) #The_white_arrows Colloid ( reddish brown ) #The_black_arrow Fibrosis septa #The_features - Nodular enlargement - Asymetrical - Firm - Show multinodular are variable in size and shape , and are separate by septa NOTE Cause Pressure symptoms due to compression of trachea and esophagus

#Microscopic #Diagnosis 👉🏻 Subacute Granulomatous thyroiditis ( Dequervain diseases) #The_black_area Gaint cell