A*STAR Research
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Subscribe to this channel to stay up-to-date with the latest scientific research and innovations from Asia. A*STAR Research is official R&D magazine for Singapore's largest science agency, the Agency for Science, Technology and Research (A*STAR).
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پستهای کانال
A drug candidate designed to work against multiple coronaviruses, not just one
As SARS-CoV-2 evolved, mutations in its spike protein allowed new variants to evade vaccine-induced immunity. A*STAR EDDC researchers turned to a different target: the coronavirus main protease (Mᵖʳᵒ), an enzyme the virus needs to replicate and that remains highly conserved across coronavirus strains.
The team designed and refined a candidate, currently called compound 18, to block the activity of Mᵖʳᵒ. The drug inhibited several SARS-CoV-2 variants as well as other coronaviruses like MERS-CoV in cultured cells, and reduced viral load in the lungs of infected mice. It also performed well in pharmacokinetic studies across several animal species, suggesting it is metabolically stable with a encouraging preclinical safety profile.
With a patent filed, the researchers say clinical trials are the next step to confirm the candidate's activity and safety.
Read the full story: https://bit.ly/4fYomrF
| 2 | Could better plant-based meat come down to enzyme dosing?
Replicating the fibrous texture of cooked chicken using plant proteins remains a challenge for meat alternatives. Enzyme activity is critical in altering protein network formation, impacting the end-product’s texture. A*STAR SIFBI and A*STAR SIMTech researchers compared three commercial proteases (enzymes that break down protein chains) to see how they affect the texture and digestibility of soy-pea meat analogues.
The team found that enzyme type and concentration both matter. At low-to-moderate doses, two of the enzymes tested improved fibrous structure, while a third caused the protein network to break down and collapse at higher concentrations, reducing chewiness by nearly 75 percent. Digestion simulations also showed that enzyme-treated samples released more soluble protein in the stomach phase compared to untreated samples.
Read the full story: https://bit.ly/3Ssce8z | 154 |
| 3 | What drives cell death in ALS? A*STAR researchers have found one of the culprits
Amyotrophic lateral sclerosis (ALS) gradually hinders a person's voluntary movement, caused by the progressive loss of motor neurons. These motor neurons carry defective mitochondria that can’t produce enough energy to sustain the cell. Restoring these powerhouses of the cell could point to therapeutic approaches for broader ALS patient groups, according to an international team led by A*STAR IMCB and A*STAR GIS researchers.
After discovering elevated levels of BLOC1S1 in degenerating ALS motor neurons, they developed RNA-targeting technology called splice-switching oligonucleotides to reduce BLOC1S1 expression. This restored mitochondrial performance, which was linked to delayed disease progression and improved survival in ALS mouse models.
The technology has been patented as a therapeutic candidate, and the approach appears to work across multiple ALS genetic subtypes.
Read the full story: https://bit.ly/4w3uNyj | 169 |
| 4 | A smooth tune-up for tiny lasers
Imagine a laser you could tune like a radio, smoothly changing its colour with a dial. Researchers at the A*STAR IMRE, working with Nanyang Technological University, Singapore, have developed a microlaser that does just that and is small enough to fit on a chip.
The design combines a phase-changing perovskite material with a specially engineered optical cavity that keeps emitted light tightly confined. Rather than relying on slow and energy-intensive external tuning methods, the microlaser switched between two emission states within the device itself, its colours shifting 20 nanometres in mere milliseconds. Moreover, the emissions stayed stable across thousands of cycles.
While some technical hurdles remain before real-world use, the researchers see several potential applications in advanced imaging, communications, sensing and display technologies.
Read the full story here: https://bit.ly/4wfyPUf | 197 |
| 5 | /stats | 1 |
| 6 |  Over the years, your input has helped drive the development of A*STAR Research—so let’s keep that momentum going 🚀
We invite readers to share their thoughts in our annual survey, which runs until 25 July 2026 (23:59 PM, SGT).
Participants also stand a chance to win a US$50 Amazon voucher! | 182 |
| 7 | Teaching AI to plan the missing steps
Show an AI model only the start and end of a task, and it has to guess the exact sequence of steps in between. This is the challenge of procedure planning, and it only gets harder when seemingly similar goals need different steps, or when there's a huge pool of possible actions to choose from.
Researchers at A*STAR I2R built VISTA-D, a framework that uses a generative AI model to come up with visual cues for the missing in-between steps, while a task-selective mask filters out irrelevant action choices. Tested across multiple datasets, the framework achieved up to 11 percent higher accuracy than a baseline model in predicting action sequences.
The team now hopes to apply the approach to sectors like manufacturing, where it could help spot defective production steps and plan alternatives to address them.
Read the full story here: https://bit.ly/44n0yGL | 185 |
| 8 | Plastic waste holds more value than we've been able to unlock, until now
Polystyrene is everywhere, from food containers to lab equipment. Once discarded, it becomes one of the most persistent forms of plastic waste. Existing upcycling methods can extract simple molecules from it, but inaccessible sites in polystyrene’s structure have long blocked chemical reactions that otherwise could have generated more valuable products. A*STAR IMRE researchers have now found a way around this barrier.
Their approach rearranges the backbone into a polyindane structure, shifting its geometry so that previously blocked sites in polystyrene's phenyl rings become reachable. An oxidation reaction at these sites then produces phthalic acid and phthalic anhydride, which are high-value chemicals used in pharmaceuticals, energy storage, dyes and advanced materials.
With a patent application filed, the team now aims to scale up the process and extend it to other polystyrene derivatives, potentially unlocking an even broader range of specialty chemicals from plastic waste.
Read the full story: https://bit.ly/3QBofYC | 195 |
| 9 | Ultrafast light pulses push electronics towards terahertz speeds
Researchers at A*STAR IMRE have found a way to harness the magnetic spin of electrons for realising terahertz (THz) devices, which could one day power next-generation communications technologies.
Working with a tiny layered device made from cobalt and strontium iridate, the team fired femtosecond laser pulses to generate ultrafast spin currents, which were then converted into transient electrical signals, effectively producing THz emissions.
Notably, the whole process works at room temperature, bypassing the need for ultralow temperature conditions that have historically made many advanced electronic effects unachievable outside lab settings. The fabrication methods used are also compatible with existing manufacturing practices, bringing real-world THz devices closer to reality.
Beyond high-speed computing and wireless communication, the researchers see potential for THz imaging and sensing applications in the medical and manufacturing sectors.
Read the full story: https://bit.ly/4xgCN0h | 166 |
| 10 | Fluorine doesn't stick around, but its impact does.
When A*STAR ISCE² researchers and their collaborators tracked copper catalysts during carbon dioxide conversion, they found something unexpected. Adding fluorine reshapes the copper surface within the first few minutes of the reaction, then leaches out almost entirely.
That reshaped catalyst surface determines whether the reaction produces simple carbon monoxide or more valuable multi-carbon fuels like ethanol and ethylene. Moderate fluorine doping produced the best results, achieving up to 81 percent selectivity towards multi-carbon products.
The findings suggest a new approach to catalyst design, one that exploits the dynamic nature of dopants as temporary sculpting tools rather than treating them as fixed components.
Read the full story here: https://bit.ly/4obtI4T | 157 |
| 11 | Granulomas don't just protect tuberculosis (TB) bacteria from the immune system. They may also create conditions for a second infection to take hold.
Researchers from A*STAR Infectious Diseases Labs (A*STAR IDL) used zebrafish models to study what happens when non-tuberculous mycobacteria (NTM) encounter pre-existing TB granulomas, which are capsules initially formed to keep TB-causing bacteria in confined spaces in the lungs. What they captured via timelapse imaging was striking: NTM streamed directly into the granuloma, where they were shielded from immune cells and fed on lipid-rich debris left over from the TB infection.
Around 25 percent of NTM patients in Singapore and the region have a recent TB diagnosis, and antibiotics for TB typically don't work against NTM. The team hopes their findings can prompt closer monitoring of co-infected patients and are exploring whether post-treatment chest X-rays could help identify those at risk early.
Read the full story here:https://bit.ly/49EZ1iw | 203 |
| 12 | Imagine getting vaccines via a painless patch rather than an injection.
Transdermal microneedle patches offer syringe-free drug and vaccine delivery through the skin, but two obstacles have kept them out of clinics: the needle tips can only hold small doses, and the protein-based medicines they carry tend to degrade quickly at room temperature.
To address this, researchers from A*STAR BTI, A*STAR SRL and A*STAR IMCB developed a microgel-integrated microneedle array patch (MI-MAP) that exploits biochemical interactions to concentrate proteins in the needle tips. Tested against conventional microneedle patches without microgel, MI-MAP showed a seven-fold increase in tip-loading volumes and nearly double the protein stability at room temperature. In mice, protein-based SARS-CoV-2 vaccines delivered via MI-MAP also triggered faster and stronger immune responses.
The team is now developing microneedle patches for delivering mRNA vaccines and therapeutics across skin and mucosal barriers.
Read the full story 👉 https://bit.ly/4voTzbX | 230 |
| 13 | Getting electrons to flow smoothly through ultrathin wires/nanoribbons at temperatures colder than outer space is no small feat.
Titanium trisulfide (TiS₃) nanoribbons are a promising material for next-generation nanoelectronics, with atomic chains that channel electrons like multi-lane highways. The snag: connecting them to conventional metals often creates resistance that worsens dramatically at ultra-low temperatures, limiting their use in quantum technologies.
Researchers from A*STAR Q.InC and A*STAR IMRE, together with collaborators from SUTD and NUS, found that indium was the right metal for the job. Its chemistry helps electrons enter TiS₃ more freely, and its low melting point allows gentler handling during fabrication. The team’s In-TiS₃ devices showed one of the lowest contact resistances reported for semiconducting nanoribbons, and even demonstrated single-electron control at 35 mK. These materials could see a variety of use cases, ranging from ultra-sensitive sensors to compact transistors for extreme environments.
Read more: https://bit.ly/49vE5dJ | 179 |
| 14 | In 3D printing titanium alloys, just a small change in machine settings can determine whether a component performs reliably or fails under pressure.
Researchers from A*STAR SIMTech and Nanyang Technological University, Singapore tested more than 100 parameter combinations to optimise electron beam powder bed fusion (PBF-EB), a 3D-printing method to produce bulk components with consistent quality.
Their findings revealed a delicate balancing act: too much energy creates pores and structural distortion, while too little leads to weak fusion defects in a titanium alloy. To adapt their work to different PBF-EB systems, the researchers also came up with a process map that helps manufacturers identify the optimal machine settings for producing stronger, more reliable components.
As additive manufacturing expands into safety-critical industries, precision at this level could make all the difference.
Read more: https://bit.ly/4wQEb9N | 193 |
| 15 | What if surgeons could access microscopic tissue insights directly in the operating theatre while an operation is ongoing?
That is the question driving Rachel Sim, Scientist at A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB) and co-founder of Ocellivision.
Using fluorescent probes and advanced imaging systems, Sim and her team are developing technologies that could give surgeons real-time, histology-like insights during operations. Their work can help with visualising disease-linked markers in cancer and neurodegenerative disorders.
In this feature, Sim also shares her journey navigating academia and Singapore’s medtech startup ecosystem.
Read the full feature here: https://bit.ly/4u2bP9X | 213 |
| 16 | 15 years of shaping science, one conversation at a time.
For a decade and a half, Sir John O'Reilly was a prominent figure of A*STAR's Science and Engineering Research Council (SERC), progressing from member to Chairman. Rather than issuing directives, his leadership philosophy was to "stir the miso soup": surface promising ideas early, foster dialogue across institutions and make space for collective wisdom to do the heavy lifting. Amidst an array of achievements, this approach helped seed cross-council collaborations between SERC and A*STAR's Biomedical Research Council (BMRC) in innovating medical technologies, and nurtured early ideas around using machine learning to accelerate materials discovery.
In this interview with A*STAR Research, the outgoing SERC Chairman shares not only his parting reflections as he steps down, but also his views on what would be key to keeping Singapore competitive in the years ahead.
Find out more about the R&D sectors and enterprise opportunities O'Reilly finds most exciting in the full story here: https://bit.ly/3RfXid4 | 247 |
| 17 | Singapore's boldest research blueprint yet just got underway.
Launched in April 2026, the RIE2030 Plan is Singapore's new five-year, S$37-billion national strategy for Research, Innovation and Enterprise. It introduces two brand new national-level programmes:
🔹RIE Flagships – targeting and advancing strategic economic sectors, one of which being thesemiconductor industry
🔹RIE Grand Challenges –coordinating research efforts across institutions to tackle urgent issues on healthy longevity and decarbonisation
A*STAR plays a central role across all four of RIE2030's domains: advanced manufacturing and connectivity, human health, sustainability, and smart and digital technologies. Besides advancing new capabilities in AI, quantum computing and biomedtech, the agency also offers fresh talent schemes to develop researchers locally and from around the region.
Check out the full story here to see what's on the horizon for Singapore's research ecosystem: https://bit.ly/4dhHTla | 184 |
| 18 | The same light used for disinfection could power next-gen sensors and detectors—if scientists can keep it from scattering.
Deep ultraviolet (DUV) light is high-energy and invisible, and while most people know it as a disinfection tool, it holds real promise for building the next generation of tiny optical devices. The problem is that when DUV light enters computer chip materials, it leaks away before it can be properly used. A*STAR researchers have now found a way to keep it in check, by combining two effects in one small structure: a nanodisk antenna that traps and concentrates the light, and a special cavity that makes the light bounce back and forth so it resonates far more strongly. Together, these effects keep DUV light focused more than 10 times longer than conventional designs.
Led by Principal Scientist Zhaogang Dong from A*STAR IMRE and A*STAR Q.InC, the team plans to use this approach to build smaller yet more efficient light detectors in next-generation devices.
Read more: https://bit.ly/434bNTK | 195 |
| 19 | 🤖 Bigger AI isn't always better AI.
When global models like GPT-4 summarise regional multilingual news, they tend to amplify the loudest voices and miss the nuances that matter most locally. Researchers at A*STAR I²R have built a smarter solution.
🗞 Meet CLUST-McMs, an AI pipeline designed specifically for regional news:
🔹 Categorisation: Groups articles by specific events (like elections or new legislation) instead of broad topics
🔹 Data sharpening: Filters out repetitive content and prioritises information-dense sentences to reduce bias
🔹 Localisation: Trains model to cite facts directly from local sources, capturing cultural nuances a global model would miss
📊 Tested on Southeast Asian news, CLUST-McMs outperformed GPT-4 across three evaluation metrics, synthesising multilingual articles into more accurate, concise and context-aware English summaries.
Next up: expanding the same regional AI intelligence to audiovisual news formats.
Read the full story here 👇 https://bit.ly/4tSuoxZ | 170 |
| 20 | Issue 52 of A*STAR Research is out now, and it arrives at a crossroads.
Singapore faces a super-aged society, an energy and climate crisis and a trillion-dollar AI revolution. Navigating these growing complexities through investments in research, innovation and enterprise lies at the heart of this issue. In our cover story, 𝘙𝘐𝘌2030: 𝘛𝘶𝘳𝘯𝘪𝘯𝘨 𝘵𝘩𝘦 𝘗𝘢𝘨𝘦, we examine A*STAR's strategic role in Singapore's new five-year R&D plan, spanning semiconductors, healthy ageing, climate adaptation and AI.
This issue also features insights from the 15 years of leadership of Sir John O'Reilly, outgoing Chairman of A*STAR's Science and Engineering Research Council, and A*STAR IMCB Scientist Rachel Sim, who went from A*STAR National Science Scholar to optical imaging startup founder. Plus: novel mRNA vaccine platforms, sustainable urban planning models and smart roadside EV chargers.
Read Issue 52 now 👇 https://bit.ly/42CtBp1 | 148 |
