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Timely Diagnosis for NTM Pulmonary Disease and Bronchiectasis | Bridging Specialties - American College of Chest Physicians
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| 15 | He was given insulin for the first time, but because the extract was not pure enough, a sterile abscess or sore formed at the injection site and the treatment failed. James Collip prepared more pure insulin within a few days. On January 23, 1922, after giving insulin for the second time, a miraculous change began. Blood sugar began to decrease, ketosis decreased, sugar in urine decreased, and the boy slowly returned from the mouth of death.
There is a widely prevalent description in history—in a hospital ward, one after another dying child was being given insulin. By the time the doctors reached the last patient, the first child had woken up from the coma. Then the second, third… one by one, the light of life returned to the dark room of death. That scene brought tears to the eyes of the attending doctors and nurses. Although the details of this event have come slightly differently in various memoirs, it still remains the most powerful symbol of the human importance of insulin's discovery.
But the story does not end here. A fierce controversy started over the credit for insulin. Banting felt that Macleod was downplaying his contribution. Charles Best's name was not getting enough importance. Banting's relationship with James Collip also broke down. In 1923, within just one year, the Nobel Prize was awarded to Frederick Banting and John Macleod. An angered Banting gave half of his prize money to Charles Best, and Macleod gave his share to James Collip. Even today, there is a debate among historians—Nicolae Paulescu, Charles Best, or James Collip—how much was whose contribution, and who were the rightful claimants of the Nobel.
Subsequently, the University of Toronto transferred the patent of insulin for just $1, so that this life-saving medicine could reach every person on earth. Eli Lilly first started large-scale insulin production. Later, at the initiative of August Krogh, production started in Scandinavia, following which Novo Nordisk was born. At first, insulin was made from the pancreas of cattle and pigs. Then in 1982, through genetic engineering, the world's first Recombinant Human Insulin came into the market. Today we are using Rapid-acting, Long-acting, Ultra-long acting insulin analogues, and have even entered the era of Once-weekly insulin.
Diabetes is not the end of life—the proof of this is many world-famous people. ✔ Swami Vivekananda ✔ Sarat Chandra Chattopadhyay ✔ Ishwar Chandra Vidyasagar, ✔ Kamal Haasan ✔ Sonam Kapoor ✔ Wasim Akram ✔ Theresa May (Type 1 Diabetes) ✔ Gary Hall Jr. (Olympic Gold Medalist, Type 1 Diabetes),
Through proper treatment, lifestyle, and awareness, a successful, long, and active life is possible even with diabetes.
Insulin is not just a medicine. It is a discovery that has changed certain death into the hope of a new life. Along with antibiotics, insulin is called one of mankind's greatest discoveries in the history of medical science.
If you have read this far, then let us know how you liked it by commenting.
✒️ Dr. Soumitra Mondal
MBBS, MD (Pulmonary Medicine),
CCEBDM (Diabetes), CCDRAI (Allergy)
Consultant Physician & Chest Specialist
Special Interest in Diabetes Management
📚 Source: Adapted from the insightful lecture of Dr. Sudip Chatterjee at IDEACon 2026, along with historical medical literature and published evidence on the discovery of insulin.
If you find the post informative, then share it on your timeline to let others know—let's become aware together.
#drsoumitra #Diabetes #Insulin #MedicalHistory #Type1Diabetes #MedicalEducation #ideacon2026 @topfans | 592 |
| 16 | 💉 The Story of Insulin’s Discovery – The discovery that changed a death sentence into the hope of a new life.
Today, we write very easily on a prescription—"Start insulin." But have you ever thought, behind this small injection lies thousands of years of history, the relentless hard work, failure, sacrifice, controversy of countless scientists, and a unique story of humanity?
Nearly 3500 years ago, in Egypt's Ebers Papyrus, the first description of such a disease was found where the patient had excessive urination. After this, in the second century AD, Greek physician Aretaeus gave a detailed description of this disease and used the word "Diabainein", which means "water passing through the body like a siphon". Later, the name Diabetes originated from this word.
The surprising thing is that in our India, Charaka and Sushruta described Madhumeha (honey urine) about 1500 years ago. They noticed that the patient's urine was so sweet that ants would swarm it. Not only that, they also divided the disease into two parts—
1) Sahaja Madhumeha, which is congenital or occurring at a young age (similar to current Type 1 Diabetes), and
2) Apathyanimittaja Madhumeha, which occurs due to excessive food intake, obesity, and an irregular lifestyle (resembling current Type 2 Diabetes).
Yet, despite knowing so much, for centuries there was no effective treatment for this disease. Especially for children, Type 1 Diabetes meant certain death. The only way to keep the patient alive was to keep them near starvation, and even then, death was only delayed by a few months.
In the late nineteenth century, the history of medical science took a new turn. In 1869, Paul Langerhans discovered small special cell clusters inside the pancreas, which later became known as the Islets of Langerhans after his name. At that time, no one knew what the function of these cells was.
About 20 years later, in 1889, Josef von Mering and Oskar Minkowski removed a dog's pancreas and saw that the dog quickly developed diabetes. Only then was it clearly understood for the first time that there is a deep relationship between Diabetes and the Pancreas.
After that, Romanian scientist Nicolae Paulescu prepared an extract from the pancreas called Pancrein, which, although capable of reducing blood sugar in animals, was not pure enough for humans. Therefore, he did not get full recognition in history. His political ideology also created intense controversy later on, and even today, many historians believe that his contribution to the history of insulin's discovery should have been recognized in a bigger way.
Just then, a groundbreaking idea came to the mind of a young Canadian surgeon, Frederick Banting. He read a research paper and realized that if the pancreatic duct could be tied off, the digestive part would degenerate, but the Islets of Langerhans would remain intact. From there, it might be possible to extract a substance that could cure diabetes. With this idea, he went to Professor John James Macleod. At first, Macleod did not really believe it because Banting was inexperienced in research and did not even know the "technique of measuring blood sugar" well. Nevertheless, he provided him with a laboratory, dogs for testing, and a medical student, Charles Best, to work with him. Later, experienced biochemist James Collip joined the team and made the extract more pure. The path of research was not easy at all. Many of the early experiments failed, many experimental dogs died, intense disagreements and quarrels started among the researchers, and even a physical altercation occurred between Banting and Collip. Just as science is a story of discovery, it is also a story of human ego, emotion, and struggle.
Then comes one of the most emotional moments in the history of medical science. On January 11, 1922, only 14-year-old Leonard Thompson was on the verge of death with severe Type 1 Diabetes and Diabetic Ketoacidosis (DKA). | 410 |
| 17 | If you read this far, please leave a comment with your thoughts below!
✒️ Dr. Soumitra Mondal
MBBS, MD (Pulmonary Medicine),
CCEBDM (Diabetes), CCDRAI (Allergy)
Consultant Physician & Chest Specialist
Special Interest in Diabetes Management
📚 Source: Adapted from the insightful lecture of Dr. Sudip Chatterjee at IDEACon 2026, along with historical medical literature and published evidence on the discovery of insulin.
*If you found this post informative, please share it on your timeline to help spread medical awareness. Let us grow healthier together.*
#drsoumitra #Diabetes #Insulin #MedicalHistory #Type1Diabetes #MedicalEducation #ideacon2026 @topfans | 286 |
| 18 | Science, as history reveals, is driven not just by clinical cold logic, but by deep human emotion, ambition, and struggle.
### The Miracle at Toronto General Hospital
Then came one of the most profoundly moving moments in medical history. On January 11, 1922, 14-year-old Leonard Thompson lay dying at Toronto General Hospital from severe Type 1 Diabetes and Diabetic Ketoacidosis (DKA). He became the first human to receive the pancreatic extract. However, because the solution was impure, it triggered severe sterile abscesses at the injection site, and the trial failed.
Working under immense pressure, James Collip spent the next twelve days refining the purification process. On January 23, 1922, young Leonard received his second injection.
The results were miraculous. His blood glucose plummeted, the life-threatening ketosis vanished, his urine cleared of sugar, and the boy was pulled back from the brink of death.
> A Legend of the Wards:
> Medical lore famously recounts an event where researchers walked through a hospital ward filled with children dying of diabetic comas, injecting them one by one with the new extract. Before they had even finished injecting the last child, the first ones began awakening from their comas, returning to life before the eyes of their weeping families. While historical accounts of this specific scene vary slightly across personal memoirs, it remains an enduring symbol of insulin's monumental human impact.
>
### Acclaim, Anger, and Global Legacy
The triumph was immediately overshadowed by bitter internal politics. Banting felt that Macleod was monopolizing the credit, while Charles Best’s contributions were being marginalized. Banting’s relationship with Collip collapsed entirely.
In 1923, the Nobel Prize Committee acted with unprecedented speed, awarding the Nobel Prize in Physiology or Medicine to Frederick Banting and John Macleod. An infuriated Banting publicly declared that he was dividing his prize money equally with Charles Best. In response, Macleod shared his portion with James Collip. To this day, medical historians debate the exact distribution of credit among Paulescu, Best, and Collip, and who truly deserved the Nobel laurels.
In a profound act of philanthropy, the University of Toronto transferred the patent rights for insulin to the public for a token $1, ensuring that this life-saving drug would remain affordable and accessible worldwide. Eli Lilly pioneered mass production in America, while August Krogh brought production to Scandinavia, laying the groundwork for what would become Novo Nordisk.
Originally sourced from the pancreases of cattle and pigs, the drug underwent a technological revolution in 1982 with the introduction of the world's first Recombinant Human Insulin via genetic engineering. Today, clinical practice utilizes rapid-acting, long-acting, and ultra-long-acting insulin analogues, and we have officially entered the era of once-weekly insulin formulations.
### Life Beyond the Diagnosis
A diabetes diagnosis is never the end of a fulfilling life. History is filled with iconic figures who managed the condition and achieved greatness:
* Swami Vivekananda
* Sarat Chandra Chattopadhyay
* Ishwar Chandra Vidyasagar
* Kamal Haasan
* Sonam Kapoor
* Wasim Akram
* Theresa May *(Type 1 Diabetes)*
* Gary Hall Jr. *(Olympic Gold Medalist, Type 1 Diabetes)*
With modern therapeutic options, structured lifestyle modifications, and proactive clinical management, patients with diabetes can live long, vibrant, and highly successful lives.
Insulin is far more than a pharmaceutical agent. It is an innovation that redefined medicine, standing alongside antibiotics as one of humanity's greatest scientific achievements. | 258 |
| 19 | 💉 The Story of Insulin’s Discovery – An Innovation That Exchanged a Death Sentence for the Hope of New Life
Today, we casually write on a prescription pad: *"Start insulin."* But have you ever paused to think about what lies behind this tiny injection? It is a rich canvas of thousands of years of medical history, tireless scientific labor, crushing failures, personal sacrifices, fierce rivalries, and an ultimate triumph for humanity.
### The Early Chapters: From Papyrus to "Madhumeha"
Nearly 3,500 years ago, Egypt’s Ebers Papyrus first recorded a mysterious illness characterized by excessive urination. By the second century AD, the Greek physician Aretaeus documented the condition in greater detail, coining the term "Diabainein," meaning "to pass through like a siphon." This later evolved into the name Diabetes.
Astonishingly, right here in India, Charaka and Sushruta described "Madhumeha" (honey urine) nearly 1,500 years ago. They observed that patients' urine was so sweet that ants would swarm around it. Remarkably, they even classified the disease into two distinct types:
1. Sahaja Madhumeha: An innate or early-onset form, closely mirroring what we know today as Type 1 Diabetes.
2. Apathyanimittaja Madhumeha: A form triggered by overeating, obesity, and a sedentary lifestyle, aligning perfectly with modern Type 2 Diabetes.
Yet, despite centuries of clinical observations, there was absolutely no effective treatment. For children diagnosed with Type 1 Diabetes, it was a swift and guaranteed death sentence. The only desperate measure available was a near-starvation diet, which merely prolonged life by a few excruciating months.
### The Biological Blueprint
The late 19th century brought a major turning point in medical science. In 1869, Paul Langerhans, a young German medical student, discovered tiny clusters of specialized cells scattered throughout the pancreas. These were later named the Islets of Langerhans, though their exact biological function remained a complete mystery at the time.
Two decades later, in 1889, Josef von Mering and Oskar Minkowski removed the pancreas of a healthy dog and observed that the animal rapidly developed severe diabetes. For the first time, science conclusively linked diabetes directly to the Pancreas.
Later, Romanian scientist Nicolae Paulescu successfully extracted a pancreatic substance he called "Pancrein." While his extract lowered blood sugar in animals, it was not pure enough for human use. Consequently, Paulescu missed out on global historical acclaim. His controversial political ideologies later clouded his legacy, though many historians still argue that his foundational contribution to insulin's history deserves far greater recognition.
### The Canadian Breakthrough & Internal Friction
This was the landscape when Frederick Banting, a young Canadian orthopedic surgeon, struck upon a revolutionary hypothesis. While reading a medical paper, he realized that if the pancreatic duct was surgically ligated, the digestive enzymes would degenerate while leaving the Islets of Langerhans intact. From these living cells, the vital anti-diabetic substance could finally be isolated.
Banting took this concept to Professor John James Macleod at the University of Toronto. Macleod was initially highly skeptical, given Banting's lack of research experience and unfamiliarity with contemporary blood glucose measurement techniques. Nevertheless, he provided Banting with a laboratory space, experimental dogs, and a sharp medical student named Charles Best. Later, James Collip, an experienced biochemist, joined the team to tackle the critical task of purifying the crude extract.
The research path was anything but smooth. Early trials failed, numerous laboratory dogs died, and intense personal egos clashed. The professional friction grew so volatile that Banting and Collip reportedly entered into a physical altercation in the lab. | 238 |
| 20 | If you read this far, please leave a comment with your thoughts below!
✒️ Dr. Soumitra Mondal
MBBS, MD (Pulmonary Medicine),
CCEBDM (Diabetes), CCDRAI (Allergy)
Consultant Physician & Chest Specialist
Special Interest in Diabetes Management
📚 Source: Adapted from the insightful lecture of Dr. Sudip Chatterjee at IDEACon 2026, along with historical medical literature and published evidence on the discovery of insulin.
*If you found this post informative, please share it on your timeline to help spread medical awareness. Let us grow healthier together.*
#drsoumitra #Diabetes #Insulin #MedicalHistory #Type1Diabetes #MedicalEducation #ideacon2026 @topfans | 232 |
