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Daptomycin 😱🤯💊💉 - The classic antibiotic associated with causing pneumonia instead of treating it is Daptomycin. Why it cannot treat pneumonia ❌ Daptomycin is inactivated by pulmonary surfactant present in the lungs. Because of this inactivation, the drug loses its antibacterial activity in lung tissue, so it cannot treat pneumonia. How it can cause pneumonia ⚠️ A known adverse effect of Daptomycin is Eosinophilic Pneumonia. This is an inflammatory lung condition where eosinophils accumulate in lung tissue, leading to breathing problems. Symptoms of Daptomycin-induced Eosinophilic Pneumonia Fever Shortness of breath Cough Hypoxia (low oxygen levels) Important GPAT / NIPER Exam Tip 🎯 🧠 Remember: “Dapto = Don’t use in lungs” One-liner often asked in exams: ➡️ Which antibiotic is ineffective for pneumonia due to surfactant inactivation? ✅ Answer: Daptomycin What Daptomycin is actually used for Complicated skin & soft tissue infections Staphylococcus aureus bacteremia Right‑sided infective endocarditis