Dr. Ben Tapper

I fixed it…

Watch and share! https://vaxxed3.childrenshealthdefense.org/vaxxed-3-movie/?fbclid=IwZXh0bgNhZW0CMTEAAR088a5KOF7FYpuCndJ33ZtAwP1mMUiKkh1T2klWpGZsnW6o97lGbs5JAT0_aem_AYcQiEhJEKZdMv1pko2znw

The Dad life is the best life! I’m so thankful for my family. What are you thankful for today? Did you know that being thankful can change our physiology? Being thankful is not just a feeling, but a powerful tool that can: -Reduce Stress and Anxiety - Decreases cortisol levels (the stress hormone) - Activates relaxation response - Lowers blood pressure - Increases serotonin and dopamine (happy hormones) - Enhances sleep quality - Improves cognitive function -Strengthen our Immune System - Increases antibody production - Activates natural killer cells - Reduces inflammation - Lower blood pressure - Reduce risk of heart disease - Improve cardiovascular function - Neuroplasticity: Gratitude rewires the brain for positivity - Hormonal balance: Gratitude regulates stress and hormones - Epigenetics: Gratitude influences gene expression Take a moment each day to reflect on the good things in your life. Write them down, share with a friend, or simply take a deep breath of gratitude. 1 Thessalonians 5:16-18

How many are struggling with help? This disaster is Lahaina2.0 and the Government is not doing anything but getting in the way and slowing progress. Next time you hear “the government is here to help,” remember: Their “help” often comes with unintended consequences.

Dr. Peter Hotez about using Homeland Security and NATO to fight anti-vaccine aggression, anti-science aggression: "I've said to the Biden administration: "The health sector can't solve this on its own, we're going to have to bring in Homeland Security, Commerce Department, Justice Department to help us understand how to do this". I met with doctor Tedros last month in Geneva, WHO the director general to say: "I don't know that the World Health Organization can solve this on our own. We need the other United Nations Agencies, NATO." This is a security problem because it's no longer a theoretical construct or some arcane academic exercise. 200,000 Americans died because of anti-vaccine aggression, anti-science aggression. And so this is now a lethal force. And now I feel as a pediatric vaccine scientist, just as it's important for me to make new vaccines to save lives, the other side of saving lives is countering this anti-vaccine aggression."

Going to get more aggressive with antivaxxers…

Danielle Smith, the premier of Alberta, Canada is the first major elected politician in the world to issue a heartfelt apology to the unvaccinated for crimes perpetrated against their human rights by the government during Covid.

what’s wrong with this world! THINGS THAT MATTER TO ME Finding God Fluoride is bad for you God is Love homeschool stuff my take on proverbs my testimony my thoughts on true christianity on when God grew skin redemption spiritual warfare The bible is smart the praying parent thinking free To Train Up A Child Uncategorized vaccination what's wrong with this world! FOLLOW BLOG VIA EMAIL Enter your email address to follow this blog and receive notifications of new posts by email. Email Address: Follow REFURBISHED ROGUE – FACEBOOK STYLE I WILL SPEAK FOR THOSE WHO CANNOT. ABOLISH HUMAN ABORTION. May 2013 M T W T F S S   1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31   « Apr   Jun » BLOGROLL Discuss Get Inspired Get Polling Get Support Learn WordPress.com Theme Showcase WordPress Planet WordPress.com News Advertisements <img src="https://sb.scorecardresearch.com/p?c1=8&c2=6820648&c3=1&c4=&c5=&c6=&cj=1&rn=1687185779190" /> REPORT THIS AD Top Posts & Pages good blogs Blogroll WordPress.com News Discuss Get Polling Learn WordPress.com WordPress Planet Get Support Theme Showcase Get Inspired Blog at WordPress.com. • Follow Privacy & Cookies: This site uses cookies. By continuing to use this website, you agree to their use. To find out more, including how to control cookies, see here: Cookie Policy <img src="https://pixel.wp.com/b.gif?v=noscript" style="height:1px;width:1px;overflow:hidden;position:absolute;bottom:1px;" alt="" />

Results: It was found in all the cases reported here the response to antigenic stimulation damaged the Beta cells in the Pancreas causing Hypoinsulinaemia which inhibited the cellular uptake of Vitamin C resulting in liver dysfunction, failure of carboxylation of the Vitamin K dependent proteins resulting in haemorrhages and fractures associated with the “triad”. Conclusion: Fractures, retinal and subdural haemorrhages and encephalopathy in children – is an autoimmune response to antigenic stimulation in a genetically susceptible individual. Common antigens are the mandated vaccines, viral bacterial and parasitic infections. ” Interpretation “In all four cases shown here there is evidence that hyperglycaemia followed vaccination and hyperglycaemia implies hypoinsulinism, an autoimmune disorder resulting from the destruction of the Beta cells of the pancreas. Since insulin is required for the transfer of vitamin C into the cells the intracellular vitamin C is reduced[12]. The resulting “tissue scurvy” compromises the function of the Liver by inhibiting carboxylation of the clotting and bone forming factors and is manifested as the signs and symptoms of the “triad”. Both Dr Kalokerinos and Professor Clemetson recommended giving the infant Vitamin C before vaccination but it would seem more appropriate to do an intradermal skin test to test for sensitivity in every case. Both were firmly of the view that a metabolic abnormality of Vitamin C was the essential cause of the signs and symptoms of the alleged “Non-accidental injuries”. ” Michael D Innis. Autoimmunity and Non-Accidental Injury in Children. Clinical Medicine Research. Vol. 2, No. 3, 2013, pp. 40-44. doi: 10.11648/j.cmr.20130203.15 Click to access 10.11648.j.cmr.20130203.15.pdf Reply the referbished rogue August 28, 2014 at 9:43 pm Thank you 🙂 I will add this along with some others. Reply Megan @LivingWhole.org September 6, 2014 at 8:37 pm Wow! You really did your research! I am very impressed and am glad I came across your blog. Keep it up. 🙂 Reply the referbished rogue September 7, 2014 at 11:01 am If this is Megan from the living whole that recently published the article about God not liking vaccines.. wow!! I am honored!! Your website is awesome. Reply Marcella Piper-Terry February 2, 2015 at 11:22 am Thank-you so much for this amazing resource! I would love to share it as a guest blog on VaxTruth.org. Reply the referbished rogue February 2, 2015 at 5:27 pm Oh wow! Thank you thank you! Of course you may! I am tickled right now 🙂 and honored for you to have read my blog!!! I love TTMR! Reply the referbished rogue February 2, 2015 at 5:31 pm I love vax truth as well.. I was so excited I don’t know what I wrote! God bless!! punyahannawilbur February 3, 2015 at 4:55 am Reblogged this on Hanna Wilbur's. Reply Lou July 22, 2015 at 11:08 pm Praise God for this site! Reply Leave a Reply Your email address will not be published. Required fields are marked * Comment * Name * Email * Website Notify me of new comments via email. Notify me of new posts via email. RECENT POSTS Abortion is forever Why we should welcome homosexuals into our churches – the thoughts of an evangelical, pentecostal Christian (no title) On Peace and the Little Girl Who Altered My Heart “Vaccines Saved Us” – Intellectual Dishonesty At Its Most Naked MOST VIEWED RECENT POSTS my list of peer reviewed vaccine research On Peace and the Little Girl Who Altered My Heart Biblical reasons to oppose vaccination Read the back of your toothpaste - fluoride IS poison. if there's doubt - GET IT OUT! WHAT WOULD YOU LIKE TO READ ABOUT? what would you like to read about? Select Category Finding God Fluoride is bad for you God is Love homeschool stuff my take on proverbs my testimony my thoughts on true christianity on when God grew skin redemption spiritual warfare The bible is smart the praying parent thinking free To Train Up A Child Uncategorized vaccination

This is a hard science, called Epigenetics. Reply Judy March 12, 2014 at 6:55 pm So many Newspapers are pushing provax messages – these journalists have not done any research. It is important to add to the comments whenever you can – not only do you educate the journalists but you may help inform the public and give another view. Love your Blog – great information, thank you so much. Reply the referbished rogue March 15, 2014 at 1:56 am Your welcome so much, Judy 🙂 it makes me happy when I get a notification that this post has been viewed by someone referred to it from a comment on a pro vax, propaganda article. God bless 🙂 Reply Chris March 14, 2014 at 2:28 am Keep up the good work!! The world is waking up. .. Reply Gabriel March 19, 2014 at 8:15 pm Thanks for doing all this work. I do have one question. How do you know that the articles are “peer reviewed”? Thanks! Reply the referbished rogue March 30, 2014 at 6:31 pm Your welcome Gabriel.. And thank you. All the links are to articles that have been published in journals that have a panel of medical / science professionals which must approve the data and the integrity of the article before it is allowed to be published. Reply David Fenton December 20, 2015 at 6:13 pm Hi, I’m developing a web site called real-morality and would like to use you list of peer reviewed articles as is, with a credit to you and link. In time I might organise them into some logical groups. My website is still in parking mode. Thanks and appreciation the referbished rogue January 16, 2016 at 9:20 pm Sure, that sounds fine. Thank you for wanting to include it. God bless, briana David September 2, 2015 at 11:00 am Most of these are from NIH. I’ve found these myself as well. You can’t get more peer-reviewed than a government health and technology agency. Reply Chris Robison March 30, 2014 at 6:04 pm bless you for doing this!! but I thought all anti-vaxxers are “anti-science”.. that’s what the science magazines all tell us.. 🙂 Reply Tina "I" April 2, 2014 at 6:48 am Wow! This is wonderful! Thanks so much for the time you have put into this, and especially for “sharing”. Everyone needs to keep getting the word out, so those that blindly follow, might eventually get their wake-up call… Hopefully, before it’s too late. Thank you! Thank you! Thank you! So nice to have it all in one place, as a reference. Reply the referbished rogue April 2, 2014 at 10:47 am Your welcome.. And thank you for commenting (every girl likes to feel special sometimes..ha) God bless! Reply Merideth April 19, 2014 at 8:34 pm Can you add a Pinterest link, so I can pin it, and keep it forever! Thanks Reply the referbished rogue April 21, 2014 at 6:06 pm Yes :)… Once I figure it out and am at my desktop..I will add it. Reply Shane Thepeopleschemist Ellison April 28, 2014 at 6:49 pm Good parent! Reply Lee June 14, 2014 at 5:21 pm Awesome job!!!!! Thanks Reply Kim July 14, 2014 at 8:37 pm Thank you SO VERY MUCH for doing this! I have been helping members of my family research this issue (some of them for the very first time); this will help tremendously. Reply Melinda Blondeaux July 27, 2014 at 12:09 pm You will probably want to add this one too: Abstract: “Background: The Shaken Baby Syndrome conceived by Guthkeltch to explain bruises, fractures, retinal and cerebral haemorrhage and encephalopathy in children, called the “triad”, can be explained by an autoimmune reaction to antigens in a genetically susceptible child. Method: Children diagnosed as suffering from Non-accidental injuries were investigated for evidence of immune response reactions following mandated vaccination and childhood illnesses.

the referbished rogue November 17, 2013 at 10:36 pm I just thought about this post..i wrote this over a year ago but this touches on our discussion and this is from my heart. https://therefurbishedrogue.wordpress.com/2012/07/03/on-the-child-i-lost-the-child-who-waits-for-me/ Pingback: Vaccine Research » My Autistic Muslim Child Pingback: Am I a murderer? | Soul Reflection shanklandfamily September 13, 2013 at 6:11 pm What an amazing list! Thank you SO MUCH for putting this together!! I have been looking for more factual information like this and your list is just what I need to get started in my reading. Your hard work is much appreciated. Reply the referbished rogue September 15, 2013 at 4:27 am So very glad to hear it. God bless! Reply Kathleen E W Bailey September 15, 2013 at 4:14 pm Reblogged this on Soul Kitty and commented: Wow, a wealth of info! Reply Sheri Nakken, former RN, MA, Hahnemannian Homeopath November 17, 2013 at 7:02 pm What an incredible list you have compiled! Wonderful and thank you. Will have to read further and see who you are! Reply the referbished rogue November 17, 2013 at 9:03 pm thank you and your welcome! ohh Lord..im afraid of what you may find. Laugh, laugh. God bless you! Reply puameliaclinic November 17, 2013 at 10:43 pm Reblogged this on The Pua Melia Clinic and commented: A page on getting some papers on Jab research Reply notidlechatter November 18, 2013 at 1:45 pm I love all the titles to your blogs. It seems as if we have been on a similar journey. I also bask in God’s grace and seek to share the truths He teaches me with others. I have a particular interest in health, wellness and avoiding vaccines. I am learning about the technology I need to get the message out more effectively. I’ve started a blog at http://www.journeyboost.com I appreciate all the work you have put in and I wish all my friends and acquaintances who want to convince me that the science supports vaccines would read every article! Thank you. Reply the referbished rogue November 18, 2013 at 4:58 pm Thank you for the encouragement! Seriously..that meant a lot to me. I can’t wait to.check out your blog 🙂 In Christ’s love and maranatha – briana Reply Lou January 7, 2014 at 6:45 am Wonderful – many thanks. In my own years of research, it always bugged me why some children / people were effected and others not (I get this question sometimes). There are a few that I recall which explains why: 1. manufacture conditions can vary and ingredients/contamination occurs in “batches”. 2. temperature control 3. varying levels of toxic additives (e.g. mercury – can be more damaging if the vial is not shaken before injection) 4. the state of the immune system 5. autism is higher in boys because of the way mercury reacts with male hormones. Just to name a few….Certain groups are used more for “guinea pig” testing than other groups. Reply the referbished rogue January 7, 2014 at 9:59 am Very good reasoning! I agree with you. It’s a shame that an industry that affects ( I really hope i used the right one there. . I always question myself ha) isn’t more aware and looking to fix these issues for the sake of the millions of children who, by blind faith, are subjected to these things. God bless you. – briana Reply David September 2, 2015 at 10:58 am It’s about genetics. Some people have gene combinations that don’t allow them to methylate the toxins in Vaccines (along with other genes that contribute to adverse reactions in other ways). Meaning, their body doesn’t detect the toxins and therefore doesn’t get rid of them, so you have Aluminum, Mercury and other carcinogenics circulating in the system or burying into cells. There are therapies such as Chelation which flush these toxins, so there is hope. The problem is that NO ONE does genetic testing prior to Vaccination to determine if this is a problem. This is why some people have adverse reactions to Vaccines and some do not.

CARMEN WHITE May 4, 2013 at 10:35 pm This is so AWESOME!!!! Thank you for taking the time to put this together. Hopefully with more people like you, we can continue to educate more parents about the harmful effects of vaccines. Reply sandy fleming May 5, 2013 at 1:53 am I am really curious, how did you find these? I thought I was pretty good at googling, but never came across so much hard science when I did my research, instead I’d come across something on “Natural News” but never able to find these peer reviewed studies. If you don’t mind sharing, can you tell me how you found most of these? Reply Pingback: my response to a friend who fears vaccination and is unsure what to do. | The Refurbished Rogue's Blog myautisticmuslimchild June 1, 2013 at 1:24 am Thank you for this post. i will be posting this link on my blog. I researched a lot, bc my son’s problem started after his 13 months vaccine (rather 12 but i was late for 1 month). i always swear by that his autism has something to do with his vaccination since he got so sick after 4 combination shots. We are still struggling, but if I can help other families to make a better decision about vaccination ut will worth all the fight. Reply the referbished rogue June 1, 2013 at 1:57 am thank you for the kind words. I don’t know how God decides which children will become autistic..but I do know that he chooses strong families who are not broken by this condition and he chooses parents like yourself who search to help others even through their own challenges. Thank you for allowing others to enter into your world and learn from your experiences. Keep fighting the good fight -briana Reply Sheri Nakken, former RN, MA, Hahnemannian Homeopath November 17, 2013 at 7:03 pm I really don’t think God decides this…………….my God doesn’t cause injury or harm or pain. It is humans who do this. the referbished rogue November 17, 2013 at 9:09 pm You are right..evil does not come from God but from sinful man. I do, however, believe that God allows bad things to happen at times for a higher purpose. For a purpose that only He knows. He allows bad things to happen only when the outcome from them will do good things. example: a Christian lady has cancer but while she is in the hospital, she witnesses to her roommate and her roommate becomes a follower of Jesus Christ. There could be two endings to this story..both good, one – the lady could receive healing and go on to live a long life. or two – the Lord could take her to spend an eternity with Him. Sheri Nakken, former RN, MA, Hahnemannian Homeopath November 17, 2013 at 9:13 pm those outcomes could happen, but a perfect loving God could NOT cause these things, or even allow these things (if allowed them, is not the perfect God). I have a different view on this. If God allows or causes, then God is not a perfect loving being. Yes, those outcomse could happen, but not because God uses us in this way. the referbished rogue November 17, 2013 at 10:06 pm The world that God intented for us to live was perfect..no pain..no sadness. But because God gave us freewill and is not a dictator..man chose to go against God and sin entered this world. From that point on..man has had to toil to eat..women scream out in pain during childbirth. But out of these hardships do you not still see love? Food to fill our bellies and children to love. The ultimate reason that I know that God is love through all the darkness..is that He sent his son Jesus Christ to die for our sins so that we may have life. Nothing that happens to us on this earth matters when you realize that heaven is ours because of what Jesus did on behalf of His Father. Just one example I would like for you look into if you like, is the book of Job. Regardless that we may see some things differently..let us keep our eyes on what really matters. Let us keep our eyes on Jesus. http://www.gotquestions.org/God-allow-Satan-attack.html

Nanomaterials can be transported by monocyte-lineage cells to DLNs, blood and spleen, and, similarly to HIV, may use CCL2-dependent mechanisms to penetrate the brain. This occurs at a very low rate in normal conditions explaining good overall tolerance of alum despite its strong neurotoxic potential. However, continuously escalating doses of this poorly biodegradable adjuvant in the population may become insidiously unsafe, especially in the case of overimmunization or immature/altered blood brain barrier or high constitutive CCL-2 production. http://www.biomedcentral.com/1741-7015/11/99 Advertisement The Role of Spiritual Enlightenment a... An Analogy with Butterfly Metamorphosis Today’s discourse touches upon the in... Share this: TwitterFacebook Loading... Related my response to a friend who fears vaccination and is unsure what to do. May 5, 2013 In "thinking free" Pediatricians Receive Regular Requests for Alternative Child Immunization Schedules..really!!? January 20, 2013 In "thinking free" what excactly is in that? March 8, 2013 In "thinking free" • Posted by the referbished rogue in vaccination Post navigation ← regarding tdap and pregnancy..is an autism coverup to blame? Read the back of your toothpaste – fluoride IS poison. if there’s doubt – GET IT OUT! → 57 thoughts on “my list of peer reviewed vaccine research” sandy fleming May 4, 2013 at 12:59 am this is amazing to say the least. Reply the referbished rogue May 4, 2013 at 1:34 am I am glad that you think so 🙂 I hope that it comes in handy for you in the future Reply Jyothi May 4, 2013 at 1:40 pm Thanks so much for putting this together! Have bookmarked and will share! Reply the referbished rogue May 4, 2013 at 1:44 pm yourwelcome! thank you so much..one person at a time.. getting the word out is how it started..and I am so thankful to whoever it was that spoke out first 🙂 I feel honored to have been “awakened”.. God bless. – briana Reply Ravi May 4, 2013 at 4:38 pm Great information all in one place. Thanks for posting and definitely sharing. BTW, the reason Polio disappeared from the map was also because the CDC renamed the disease to Aseptic Viral meningitis and also Acute Flaccid Paralysis. You can see that just about these two diseases were brought forth the numbers for these went up while the numbers for polio disappeared. Not sure if this was mentioned in the article (did not read all of it yet :)). Thanks again Reply the referbished rogue May 4, 2013 at 5:07 pm Ravi, thank you so very much for reminding me about this! unfortunately, this list is what survived a computer crash and then a new computer. I lost so so so much stuff..so much knowledge forgotten..but, I don’t mind it all that much..i look forward to finding them all again. The renaming of polio scam did not make it on my list, I don’t think. I remember reading about it a long time ago on an ‘InsideVaccines’ post and it led me to find the studies and such..but apparently that lead is just one of many lost 😦 but now that you have reminded me of it..im off to do some research and will hopefully be adding this to my list tonight. any thing else you’d like to remind me of? ha 🙂 God bless – briana Reply Sheri Nakken, former RN, MA, Hahnemannian Homeopath November 17, 2013 at 7:01 pm and also wherever polio was, there was DDT use http://www.wellwithin1.com/Polio.West.htm Gayl H May 4, 2013 at 6:32 pm What a great start! Like you, I have read 100s if not thousands of articles, and have been trying to put together a compendium such as this on paper/computer, but didn’t think of archiving them like this! Excellent “abstracting” of the articles as well! This is a tremendous service to all who are trying to research vaccine safety 🙂 Reply the referbished rogue May 4, 2013 at 7:40 pm I am just overwhelmed by all the kind comments.. thank you Gayl H. When ever you get yours completed I would love to take a peek. if you remember me then..let me know 🙂 -briana Reply

The predominance in these outbreaks of infected people of university age not only highlights an environment with potential for increased transmission but also raises questions about the efficacy of the MMR vaccine. The people affected may represent a “lost cohort” who do not have immunity from natural mumps infection and were not offered a 2-dose schedule. Given the current level of mumps activity around the world, clinicians should remain vigilant for symptoms of mumps. http://www.ncbi.nlm.nih.gov/pubmed/16940266   Persistence of maternal antibody in infants beyond 12 months: Mechanism of measles vaccine failure A serologic study was made in 34 children immunized against measles at the age of 12 months. Using a sensitive virus neutralization test, it was found that many of the children had pre-existing maternal antibody to measles virus. (this was written in 1977 back when mothers were actually passing immunity to their children..this is just an example of natural immunity being passed from mother to child..something that vaccination cannot and will not ever do.) http://www.sciencedirect.com/science/article/pii/S0022347677810214 The study, which analyzed data from 2009-2011, found that white, college-educated mothers over the age of 35 were most likely to report that they had delayed or skipped immunizations for their children. There’s no consensus as to why that is the case, Young said. [hmmm..lets try to help them come to a clear consensus.. could intellence level be a factor? could age play a role because mothers over 35 have had more time to witness what vaccination can do?] Read more here: http://www.adn.com/2013/04/22/2875131/more-alaskans-hesitant-about-vaccines.html#storylink=cpy “A Positive Association found between Autism Prevalence and Childhood Vaccination uptake across the U.S. Population” The reason for the rapid rise of autism in the United States that began in the 1990s is a mystery. Although individuals probably have a genetic predisposition to develop autism, researchers suspect that one or more environmental triggers are also needed. One of those triggers might be the battery of vaccinations that young children receive. Using regression analysis and controlling for family income and ethnicity, the relationship between the proportion of children who received the recommended vaccines by age 2 years and the prevalence of autism (AUT) or speech or language impairment (SLI) in each U.S. state from 2001 and 2007 was determined. A positive and statistically significant relationship was found: The higher the proportion of children receiving recommended vaccinations, the higher was the prevalence of AUT or SLI. A 1% increase in vaccination was associated with an additional 680 children having AUT or SLI. Neither parental behavior nor access to care affected the results, since vaccination proportions were not significantly related (statistically) to any other disability or to the number of pediatricians in a U.S. state. The results suggest that although mercury has been removed from many vaccines, other culprits may link vaccines to autism. Further study into the relationship between vaccines and autism is warranted   full text: http://www.theoneclickgroup.co.uk/documents/vaccines/Vaccine%20and%20Autism%20correlation%20US%202011%20J%20Tox%20Env%20Health.pdf     “CDC officials discuss neurological damage from vaccines in secret meeting – Simpsonwood” You can read this clearly for yourself if you access the pdf transcript that was obtained via FOIA http://therefusers.com/refusers-newsroom/cdc-officials-discuss-neurological-damage-from-vaccines-in-secret-meeting-simpsonwood/#.UYM4l07D_IV “The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects  The odds of having had any allergy-related respiratory symptom in the past 12 months was 63% greater among vaccinated subjects than unvaccinated subjects” http://www.ncbi.nlm.nih.gov/pubmed/10714532

There were 415 arthritis, 166 rheumatoid arthritis, 130 myelitis, 4 SLE, 100 optic neuritis, 101 GBS, 29 glomerulonephritis, 283 pancytopenia/thrombocytopenia, and 183 MS events reportedfollowing HBV A total of 465 positive re-challenge adverse events were observed following adult HBV that occurred sooner and with more severity than initial adverse event reports. A case-report of arthritis occurring in identical twins was also identified. [personal note: between 1 and 10 percent of adverse events are actually reported according to the FDAs David Kessler) http://www.ncbi.nlm.nih.gov/pubmed/15638050 Viral proteins having molecular mimicry with self-proteins in the CNS can prime genetically susceptible individuals. Once this priming has occurred, an immunologic challenge could result in disease through bystander activation by cytokines. Read More: http://informahealthcare.com/doi/abs/10.1080/08916930500484799 Nevertheless, allergy and, to a lesser extent, autoimmunity have repeatedly been described or suspected as rare adverse consequences of human vaccines. The mechanisms of these adverse reactions are ill-elucidated, if at all. No animal models have been adequately standardized and validated to predict the risk of allergy and autoimmunity associated with vaccines. However, a number of existing models can be considered for use, but need refinement to be applied to vaccine evaluation. Finally, because the preclinical safety evaluation has not received much attention in the past, efforts should be paid to design specific and cost-effective procedures to meet the current expectations. http://www.sciencedirect.com/science/article/pii/S0300483X02000562 After reviewing the 27 cases of vasculitis after hepatitis B vaccination reported in the current literature, the authors suggest that, in some cases, vaccination may be the triggering factor for vasculitis in individuals with a genetic predisposition. Physicians should be aware of this possible association. http://www.sciencedirect.com/science/article/pii/S0953620508000770 Mumps resurgences in the United States: A historical perspective on unexpected elements. . The 2006 epidemic followed this pattern, with two unique variations: it was preceded by a period of very high vaccination rates and very low disease incidence and was characterized by two-dose failure rates among adults vaccinated in childhood. Data from the past 80 years suggest that preventing future mumps epidemics will depend on innovative measures to detect and eliminate build-up of susceptibles among highly vaccinated populations http://www.ncbi.nlm.nih.gov/pubmed/19815120 Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation. http://www.ncbi.nlm.nih.gov/pubmed/22111471 However, a 2006 epidemic involved >5700 cases nationwide, with many reported among fully vaccinated college students.. A large mumps outbreak occurred despite high two-dose vaccination coverage in a population most of whom had received the second dose >10 years before. Two-dose vaccine effectiveness was similar to previous one-dose estimates. Further studies are needed to examine the persistence of two-dose mumps vaccine-induced immunity and to determine whether US mumps elimination can be achieved with the current vaccination strategy. http://www.ncbi.nlm.nih.gov/pubmed/18539365 The first outbreak involved 13 high-school students (median age 14 yr): 9 who had previously received 2 doses of measles-mumps-rubella vaccine (MMR) and 4 who received a single dose. The second outbreak comprised 19 cases of mumps among students and some staff at a local university (median age 23 yr), of whom 18 had received only 1 dose of MMR (the other received a second dose). The viruses identified in the outbreaks were phylogenetically similar and belonged to a genotype commonly reported in the UK. The virus from the second outbreak is identical to the strain currently circulating in the UK and United States. INTERPRETATION:

Conclusions: Our results suggest that vaccines other than influenza vaccine can be associated with GBS. Vaccination-related GBS results in death or disability in one fifth of affected individuals, which is comparable to the reported rates in the general GBS population http://journals.lww.com/jcnmd/Abstract/2009/09000/Guillain_Barre_Syndrome_after_Vaccination_in.1.aspx Autoimmune reactions to vaccinations may rarely be induced in predisposed individuals by molecular mimicry or bystander activation mechanisms. Autoimmune reactions reliably considered vaccine-associated, include Guillain-Barré syndrome after 1976 swine influenza vaccine, immune thrombocytopenic purpura after measles/mumps/rubella vaccine, and myopericarditis after smallpox vaccination, whereas the suspected association between hepatitis B vaccine and multiple sclerosis has not been further confirmed, even though it has been recently reconsidered, and the one between childhood immunization and type 1 diabetes seems by now to be definitively gone down. Larger epidemiological studies are needed to obtain more reliable data in most suggested associations. Read More: http://informahealthcare.com/doi/abs/10.3109/08830181003746304 Vaccines, in several reports were found to be temporally followed by a new onset of autoimmune diseases. The same mechanisms that act in infectious invasion of the host, apply equally to the host response to vaccination. It has been accepted for diphtheria and tetanus toxoid, polio and measles vaccines and GBS. Also this theory has been accepted for MMR vaccination and development of autoimmune thrombocytopenia, MS has been associated with HBV vaccination. Read More: http://informahealthcare.com/doi/abs/10.1080/08916930500050277 Hepatitis B infection is one of the most important causes of acute and chronic liver disease. During the 1980s, genetically engineered hepatitis B vaccines (HBVs) were introduced in the United States. A large-series of serious autoimmune conditions have been reported following HBVs, despite the fact that HBVs have been reported to be “generally well-tolerated.” A case-control epidemiological study was conducted to evaluate serious autoimmune adverse events prospectively reported to the vaccine adverse events reporting system (VAERS) database following HBVs, in comparison to an age, sex, and vaccine year matched unexposed tetanus-containing vaccine (TCV) group for conditions that have been previously identified on an a priori basis from case-reports. Adults receiving HBV had significantly increased odds ratios (OR) for multiple sclerosis (OR = 5.2, p < 0.0003, 95% Confidence Interval (CI) = 1.9 – 20), optic neuritis (OR = 14, p < 0.0002, 95% CI = 2.3 – 560), vasculitis (OR = 2.6, p < 0.04, 95% CI = 1.03 – 8.7), arthritis (OR = 2.01, p < 0.0003, 95% CI = 1.3 – 3.1), alopecia (OR = 7.2, p < 0.0001, 95% CI = 3.2 – 20), lupus erythematosus (OR = 9.1, p < 0.0001, 95% CI = 2.3 – 76), rheumatoid arthritis (OR = 18, p < 0.0001, 95% CI = 3.1 – 740), and thrombocytopenia (OR = 2.3, p < 0.04, 95% CI = 1.02 – 6.2) in comparison to the TCV group. Minimal confounding or systematic error was observed. Despite the negative findings of the present study regarding the rare serious adverse effects of HBVs, it is clear that HBV does, indeed, offer significant benefits, but it is also clear that chances of exposure to hepatitis B virus in adults is largely life-style dependent. Adults should make an informed consent decision, weighing the risks and benefits of HBV, as to whether or not to be immunized http://www.ncbi.nlm.nih.gov/pubmed/16206512 HBV was associated with a number of serious conditions and positive re-challenge or significant exacerbation of symptoms following immunization.

found to be homologous to myelin basic protein (23). 2) Another coincidental infection: Most of the vaccine recipients are at high risk for infection with EBV, C M V and HTLV 3, that also can cause demyelinating disease (18). 3) Immune complex disease: Five cases of GBS have been reported in patients suffering from infection with HBV. In the acute phase of GBS, immune complexes containing hepatitis B surface antigen were found in the serum and cerebrospinal fluid, but not in the sural nerve. Those immune complexes were not present when the hepatitis was first detected, but only after the appearance of neurological symptoms, and disappeared when the inflammatory phase of the disease had ended (24, 25). Immune complexes without a known antigen were found in other cases of GBS in various organs. The immune complexes can transfer through the blood-nerve barrier and may be deposited in the endonerium and injure nerve fibers (25). Treatment with plasmapheresis or IVIG may eliminate those immune complexes. R e c e n t l y, the presence of glycolipid (ganglioside) specific antibodies has been found to be associated with neurological disease, in particular with GBS. The pathogenic potential of these antibodies has remained unclear. Several mechanisms by which anti-ganglioside antibodies may exert their potential pathogenic effect have been proposed. Direct binding of anti-ganglioside antibodies to axon or Schwann cells might disturb ion fluxes and cause partial nerve conduction block (26). Naturally occurring antibodies crossre – acting with gangliosides may become pathogenic after affinity maturation and class switching initiated by preceding infection. The hepatitis B vaccine has been used routinely for almost 20 years. Most of the side effects are local or transient minor reactions. The rate of the adverse events is 1 in 15,500 doses. Major reactions are rare and include variable autoimmune phenomena: erythema nodosum, lichen planus, acute urticaria, polyarthritis, including rheumatoid arthritis and reactive arthritis, vasculitis, glomerulonephritis, Evan’s syndrome and thrombocytopenic purpura. Neurological complications include acute cerebellar ataxia and autoimmune demyelinating disorders including multiple sclerosis, transverse myelitis and GBS (27). These reactions are sporadic and there is no clear evidence that the rate of GBS or multiple sclerosis is more common among the vaccinated population. Hepatitis B vaccine is important and, according to the available data, the prevention of hepatitis B outweighs the rare incidence of diseases reported after vaccination. Further animal studies and evaluation of the risk factors for these adverse effects are indicated. http://www.clinexprheumatol.org/article.asp?a=2492 Guillain-Barre Syndrome after Vaccination in United States: Data From the Centers for Disease Control and Prevention/Food and Drug Administration Vaccine Adverse Event Reporting System (1990-2005) Methods: We used data for 1990 to 2005 from the Vaccine Adverse Event Reporting System, which is a cooperative program of the Centers for Disease Control and Prevention and the US Food and Drug Administration. Results: There were 1000 cases (mean age, 47 years) of GBS reported after vaccination in the United States between 1990 and 2005. The onset of GBS was within 6 weeks in 774 cases, >6 weeks in 101, and unknown in 125. Death and disability after the event occurred in 32 (3.2%) and 167 (16.7%) subjects, respectively. The highest number (n = 632) of GBS cases was observed in subjects receiving influenza vaccine followed by hepatitis B vaccine (n = 94). Other vaccines or combinations of vaccines were associated with 274 cases of GBS. The incidence of GBS after influenza vaccination was marginally higher in subjects <65 years compared with those ≥65 years (P = 0.09); for hepatitis vaccine, the incidence was significantly higher (P < 0.0001) in the <65 group. Death was more frequent in subjects ≥65 years compared with those <65 years (P < 0.0001).