Pathology videos & books

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Correct Answer - C Answer- C. Membrane defect * Among the defects in hexose monophosphate shunt, the most common is G6PD deficiency. * G6PD gene is located on the X chromosome and its deficiency is, therefore, a sex (X)-linked trait affecting males, while the females are carriers and are asymptomatic. * PATHOGENESIS: Normally, red blood cells are well protected against oxidant stress because of an adequate generation of reduced glutathione via the hexose monophosphate shunt. * Individuals with inherited deficiency of G6PD, an enzyme required for hexosemonophosphate shunt for glucose metabolism, fail to develop adequate levels of reduced glutathione in their red cells. * The clinical manifestations are those of acute hemolytic anemia within hours of exposure to oxidant stress. * The hemolysis is, however, self-limiting even if the exposure to the oxidant is continued since it affects the older red cells only @sketchymedical

Correct Answer - D Answer- D. 2 A normal CD4/CD8 ratio is 2.0, with CD4 lymphocytes equal to or greater than 400/mm3 and CD8 lymphocytes equal to 200 to 800/mm3. @sketchymedical