Journals | Журналы (Impact Factor)

The pathogenesis of Parkinson's disease (PD) is based on the deposition of large protein complexes in brain neurons that are toxic to nerve cells. Studies show that the protein alpha synuclein found mainly in presynaptic terminals leads to the death of dopaminergic neurons in the brain. Patients with Parkinson's disease often complain of digestive problems years before the onset of motor disorders. Gastrointestinal dysfunction in PD is manifested by a variety of non-motor as well as motor symptoms, and every segment of the gastrointestinal tract is affected.

Uveitis is a group of severe inflammatory diseases of the eyeball that can lead to such serious complications as decreased vision and even blindness. Of great importance in the pathogenesis of inflammation of the vascular layer of the eyeball is dysregulation of immune mechanisms, carried out by a large number of humoral mediators. Among them, cytokines occupy a special place. <i><b>Purpose:</b></i> to study the concentration of a number of cytokines in blood plasma and analyze changes in the cytokine profile depending on the severity of the inflammatory process in uveitis. <i><b>Materials</b></i> <i><b>and</b></i> <i><b>methods.</b></i> The subjects of the study were 45 patients (20 men and 25 women), examined and treated with a diagnosis of chronic uveitis in the hospital of the Bukhara branch of the Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery (Bukhara, Uzbekistan). 22 patients who did not have inflammatory diseases in the organ of vision were selected as a control group.…

The article reveals the relevance of the problem of coronavirus infection in children, examines the risks of the disease, neurological manifestations, laboratory data, and considers options for the severe course of the disease.

Orofacial pain, according to the international pain community, accounts for about 20% of the world population. the main pathomechanism of facial pain, is a violation of the relationship of several parameters of muscles, bone, occlusion, adjacent joints, psychoemotional lability, age-related jaw deformity, periodontal disease, etc. The nature of the pain syndrome itself is also not unambiguous, the chronicization of the process in terms of formation, as well as the frequency of recurrences of the disease, independent of age, climatic conditions.

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