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Indications of Growth Hormone Therapy :
(1) Russell-Silver syndrome
(2) chondrodysplasia in children
(3) steroidinduced growth suppression
(4) short stature associated with myelomeningocele
(5) any severe wasting state (e.g., wounds, burns, cancer)
(6) normal aging
(7) non–islet cell tumor hypoglycemia
(8) gonadal dysgenesis
(9) Down’s syndrome
(10) short stature associated with neurofibromatosis
(11) human immunodeficiency virus ( HIV ) associated adipose redistribution syndrome
(12) osteoporosis.
Source : Endocrine Secrets 7th ed 2020
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When should basal insulin be taken?
• Insulin glargine U-100, detemir, glargine U-300, and degludec should be taken once a day at the same time
each day.
• Insulin glargine U-100 or detemir may be taken at bedtime if the “dawn phenomenon” is present.
• Basal insulin analogues (glargine, detemir, or degludec) cannot be mixed with other insulins.
• If nocturnal hypoglycemia results from taking a full dose of glargine or detemir at bedtime, an option would be
to split the dose so that 50% is taken in the morning and the other 50% is taken in the evening, approximately
12 hours apart.
• NPH insulin is taken in the morning and at bedtime to avoid nocturnal hypoglycemia.
• Doses of insulin glargine U-300 and insulin degludec should not be adjusted more frequently than every 3 to
4 days because of their longer half-lives
Source : . Endocrine Secrets 7th ed 2020
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Hyperbaric Oxygen Therapy_ Principles and Applications 2023
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