Come Don Chisciotte PIU' SALUTE di Valentina Bennati
Non c’è niente di più incontrollabile di una persona sana, consapevole e felice.
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<p>Melatonin is an endogenous indoleamine that has been shown to inhibit tumor growth in laboratory models of prostate cancer. Prostate cancer risk has additionally been associated with exogenous factors that interfere with normal pineal secretory activity, including aging, poor sleep, and artificial light at night. Therefore, we aim to expand on the important epidemiological evidence, and to review how melatonin can impede prostate cancer. More specifically, we describe the currently known mechanisms of melatonin-mediated oncostasis in prostate cancer, including those that relate to the indolamine’s ability to modulate metabolic activity, cell cycle progression and proliferation, androgen signaling, angiogenesis, metastasis, immunity and oxidative cell status, apoptosis, genomic stability, neuroendocrine differentiation, and the circadian rhythm. The outlined evidence underscores the need for clinical trials to determine the efficacy of supplemental, adjunct, and adjuvant melatonin therapy for the prevention…
Di Federico Degg per ComeDonChisciotte.org Il 12 marzo 2024, secondo alcuni, può essere visto come data storica: in tale giornata l’NHS, ovvero il sistema sanitario nazionale del Regno Unito, ha annunciato lo stop alla somministrazione di bloccanti della pubertà ai minori presso le cliniche ad esso appartenenti che si occupano di identità di genere [1]. […]
Non c’è niente di più incontrollabile di una persona sana, consapevole e felice.
di Valentina Bennati comedonchisciotte.org La vitamina D aiuta i batteri intestinali a suscitare l’immunità al cancro, lo evidenzia uno studio appena pubblicato su Science. In sostanza i ricercatori hanno osservato che la vitamina D può regolare il microbioma intestinale favorendo un tipo di batteri che conferisce ai topi una migliore resistenza ai tumori e questa scoperta potrebbe rivelarsi molto importante anche per il trattamento del cancro negli esseri umani,
Gut microbiota plays a crucial role in inflammatory bowel diseases (IBD) and can potentially prevent IBD through microbial-derived metabolites, making it a promising therapeutic avenue. Recent evidence suggests that despite an unclear underlying mechanism, red cabbage juice (RCJ) alleviates Dextran Sodium Sulfate (DSS)-induced colitis in mice. Thus, the study aims to unravel the molecular mechanism by which RCJ modulates the gut microbiota to alleviate DSS-induced colitis in mice. Using C57BL/6J mice, we evaluated RCJ’s protective role in DSS-induced colitis through two cycles of 3% DSS. Mice were daily gavaged with PBS or RCJ until the endpoint, and gut microbiota composition was analyzed via shotgun metagenomics. RCJ treatment significantly improved body weight (p ≤ 0.001), survival in mice (p < 0.001) and reduced disease activity index (DAI) scores. Further, RCJ improved colonic barrier integrity by enhancing the expression of protective colonic mucins (p < 0.001) and tight junction proteins (p ≤ 0.01) in…
Non c’è niente di più incontrollabile di una persona sana, consapevole e felice.
di Valentina Bennati comedonchisciotte.org A precedenti studi che avevano già evidenziato le potenziali applicazioni terapeutiche basate sulle attività immunomodulanti e antinfiammatorie dell'alga spirulina, si è aggiunto un interessante lavoro iraniano che ha evidenziato la capacità di questa particolare alga blu-verde di migliorare la funzione cognitiva e i parametri dell'omeostasi del glucosio nei pazienti con Alzheimer.
Background: The increasing prevalence of food sensitivities has been attributed to changes in gut microenvironment; however, ubiquitous environmental triggers such as inorganic nanoparticles (NPs) used as food additives have not been thoroughly investigated. Objectives: We explored the impact of the NP-structured food-grade silicon dioxide (fg-SiO2) on intestinal immune response involved in oral tolerance (OT) induction and evaluated the consequences of oral chronic exposure to this food-additive using a mouse model of OT to ovalbumin (OVA) and on gluten immunopathology in mice expressing the celiac disease risk gene, HLA-DQ8. Methods: Viability, proliferation, and cytokine production of mesenteric lymph node (MLN) cells were evaluated after exposure to fg-SiO2. C57BL/6J mice and a mouse model of OT to OVA were orally exposed to fg-SiO2 or vehicle for 60 d. Fecal lipocalin-2 (Lcn-2), anti-OVA IgG, cytokine production, and immune cell populations were analyzed. Nonobese diabetic (NOD) mice expressing HLA-DQ8…
Phytotherapy Research is a medicinal chemistry journal for biochemists, pharmacologists, & toxicologists interested in medicinal plant research & clinical applications.