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⭐ ПЕДИАТР l АРТУР МАЗАЕВ 𝙍𝙚𝙨𝙚𝙖𝙧𝙘𝙝-𝘽𝙖𝙨𝙚𝙙 𝙈𝙚𝙙𝙞𝙘𝙞𝙣𝙚 ❗ХОЛИСТИЧЕСКАЯ ПЕДИАТРИЯ Основатель проекта "𝑻𝒉𝒆 𝑽𝒂𝒄𝒄𝒊𝒏𝒆 𝑭𝒓𝒊𝒆𝒏𝒅𝒍𝒚 𝑷𝒍𝒂𝒏" #ᴠᴀᴄᴄɪɴᴇғʀɪᴇɴᴅʟʏᴅᴏᴄᴛᴏʀ instagram.com/mazaevdoc arturmazaev.com
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Prunus armeniaca L. (Rosaceae)-syn. Amygdalus armeniaca (L.) Dumort., Armeniaca armeniaca (L.) Huth, Armeniaca vulgaris Lam is commonly known as the apricot tree. The plant is thought to originate from the northern, north-western, and north-eastern provinces ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell infection and cell-cell fusion that causes stabilization of tumor suppressor p53 protein. In-silico analysis previously suggested that SARS-CoV-2 spike interacts with p53 directly but this putative interaction has not been demonstrated in cells. We examined the interaction between SARS-CoV-2 spike, p53 and MDM2 (E3 ligase, which mediates p53 degradation) in cancer cells using an immunoprecipitation assay. We observed that SARS-CoV-2 spike protein interrupts p53-MDM2 protein interaction but did not detect SARS-CoV-2 spike bound with p53 protein in the cancer cells. We further observed that SARS-CoV-2 spike suppresses p53 transcriptional activity in cancer cells including after nutlin exposure of wild-type p53-, spike S2-expressing tumor cells and inhibits chemotherapy-induced p53 gene activation of p21(WAF1), TRAIL Death Receptor…
More vaccinated people are regreting taking the jab, according to a report which details rising anger at the unvaccinated for not warning the world about the dangers.