GiT Updates and More

Statin side effect management: *If pain and CK normal… Hold statin and restart at lower dose *If CK mildly elevated (<10 X ULN) ….. Restart at lower dose or switch statin *If CK markedly elevated (>10 X)… Stop statins permanently

Hyperthyroidism in Pregnancy: Propylthiouracil is used in the first trimester of pregnancy in place of carbimazole ( risk of congenital abnormalitie. At the beginning of the second trimester, the woman should be switched back to carbimazole.

Miracle Drug Class of 2022 SGLT2 inhibitors Empagliflozin, Dapagliflozin, Ertugliflozin, Canagliflozin *Lowers mortality in CHF with systolic dysfunction *Decreases progression of chronic kidney disease (CKD) *Use in CKD with proteinuria, even without diabetes

Sarin classification of esophageogastric varices

Cryoprecipitate is derived from fresh frozen plasma and contains factor VIII, factor XIII, fibrinogen, vWF and fibronectin. It is used to treat fibrinogen deficiency in cases of disseminated intravascular coagulation, trauma, invasive procedures or haemorrhage. It is more commonly used to treat an intracranial haemorrhage secondary to tissue plasminogen activator use for an acute ischaemic stroke.