MedPharm || طبصيدلة

58 years old man (life expectancy is about 20 years) who suffers from urinary frequency and hesitancy. He was diagnosed to have stage 3 prostate cancer. A biopsy was obtained and Gleason score was 8. Lab data shows prostate specific antigen of 30ng/ml. The patient has a medical history of osteoarthritis and celiac disease. Initial treatment for this patient depends on all of the following factors EXCEPT: a- Life expectancy b- Symptoms c- Gleason score d- Comorbid conditions e- Disease stage

Prostate cancer pharmacological therapy may involve the use of many drugs. A patient diagnosed with castrate-refractory prostate cancer (CRPC). All the following can be indicated for the treatment of CRPC patients, EXCEPT: a- Docetaxel b- Radium-223 c- Apalutamide d- Trastuzumab e- Enzalutamide

Which of the following is an effective method to decrease the tumor flare syndrome of prostate cancer associated with the first few weeks of LHRH agonist therapy? a- Start the LHRH agonist with a loading dose to rapidly achieve steady-state levels b- Start an antiandrogen before the LHRH agonist and continue for the first 3 to 4 weeks of therapy c- Start the LHRH agonist with a 50% dose decrease, slowly titrating to a full dose over 3 to 4 weeks d- Alternate LHRH agonists during the first 3 to 4 months of therapy e- Maintain testosterone levels above castration levels

58-year-old male presented with a PSA of 17.9 ng/ml, T3 and Gleason 7 (3+4) and diagnosed with prostate adenocarcinoma as castration-resistant prostate cancer. Which of the following antiandrogens is FDA approved for castration-resistant prostate cancer and can be used as the first-line setting to delay the initiation of chemotherapy in both nonmetastatic and metastatic disease? a- Bicalutamide b- Enzalutamide C- Nilutamide d- Flutamide e- Abiraterone

The followings are correct regarding the pathophysiology of prostate cancer EXCEPT A- Well-differentiated tumors grow slowly. B- Adenocarcinoma cells Include 95% of cases. C- The kidney is the most organ Involved initially in metastasis D- The rationale for hormone therapy is based on the effect of androgen on the growth and differentiation of the normal prostate E- Localized prostate cancer is curable by surgery or radiotherapy

Regarding management of prostate cancer. Which of the following regarding the combination of (flutamide and leuprolide) is true? A- It is indicated to delay the initiation of chemotherapy in both nonmetastatic and metastatic disease. B- It is indicated for advanced prostate cancer. C- It is indicated for orchiectomy. D- It is indicated for metastatic castrate-resistant prostate cancer. E- It is indicated as adjuvant therapy before mastectomy.