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1 406
Large,irregular opening called the aditus to the mastoid antrum present in
1 406
A 35-year-old patient presents with severe ulcerative necrotic lesions on the tonsils and other areas of the oropharynx. He appears acutely ill. Laboratory results reveal a total white blood cell count of 50/cu mm, with polymorphonuclear cells less than 5%.
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اللهمَّ صلِ على محمَّد وعلى آل محمَّد، كما صليتَ على إبراهيم وعلى آل إبراهيم، إنَّك حميد مجيد. اللهمَّ بارِك على محمَّد وعلى آل محمد، كما باركتَ على إبراهيم وعلى آل إبراهيم، إنَّك حميدٌ مجيد
بِ نية تسهيل الأمور ♥️🍀
1 406
A 17-year-old boy presents to the emergency department with painful mouth ulcers, red eyes, and a rash that started 2 days ago. He had a chest infection one week ago and was given azithromycin. On exam, he has conjunctival redness, oral mucosal erosions, and target lesions on his hands, arms, and trunk. He is febrile and appears uncomfortable.
A. Erythema multiforme major
B. Stevens-Johnson syndrome (SJS)
C. Kawasaki disease
D. Pemphigus vulgaris
E. Erythema multiforme minor
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1. Ichthyosis Vulgaris
• Inheritance: Autosomal dominant
• Gene/Defect: Mutation in filaggrin gene
• Note: Commonly associated with atopy; improves with age.
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2. X-linked Ichthyosis
• Inheritance: X-linked recessive
• Gene/Defect: Steroid sulfatase deficiency (enzyme defect)
• Note: Affects males; associated with corneal opacities and delayed labor.
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3. Acquired Ichthyosis
• Inheritance: Not inherited (secondary)
• Associated with:
• Most common hidden cause: Hypothyroidism
• Also linked to malignancies (e.g., lymphoma), sarcoidosis, AIDS, etc.
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4. Neurofibromatosis Type 1 (Von Recklinghausen’s Disease)
• Inheritance: Autosomal dominant
• Gene/Defect: Mutation in NF1 gene, which encodes neurofibromin (a tumor suppressor)
• Note: Café-au-lait spots, neurofibromas, Lisch nodules; 50% new mutations.
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5. Tuberous Sclerosis (Epiloia)
• Inheritance: Autosomal dominant
• Note: Triad of epilepsy, low intelligence, facial angiofibromas.
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6. Xeroderma Pigmentosum
• Inheritance: Autosomal recessive
• Gene/Defect: Deficiency in endonuclease enzyme responsible for repairing UV-induced DNA damage
• Note: Severe photosensitivity, early-onset skin cancers.
