قسم الـعملي "LAB Section"_الدفعة السادسة

🔻Hashimoto thyroiditis, microscopic 🔷االدائرة الزرقاء -----> Lymphoid Follicles 🔺السهم الاحمر----> Hurthle Cell وهذه مميزة للمرض ◾️الاسهم السوداء -----> atrophic follicles وبداخلها colloid #شرح_عملي

🔻Hashimoto thyroiditis, microscopic 🔹This low power microscopic view of thyroid gland shows an early stage of Hashimoto thyroiditis with prominent lymphoid follicles نلاحظ وجود prominent lymphoid follicles لان عاده في Early stage ◾️الاسهم السوداء تشير الى Germinal Center ▫️والنقاط الزرقاء تشير الاسهم تشير الى تجمع Lymphocytes في اطراف germinal

🔻Hashimoto thyroiditis, Atrophic gland gross 🔹There is relentless destruction of thyroid follicles over the years, with eventual atrophy يحصل الـ atrophy بسبب تدمر الـ Follicles ويكون Symmetrical #شرح_عملي

🔻Hashimoto Thyroiditis Cut surface 🔹 pale ,yellow-tan ,firm ,nodular ;resembles lymph nodes ◽️السهم الابيض ----> Normal tissue ▪️السهم الاسود -----> Lymphoid follicles

السلام عليكم ورحمة الله وبركاته 🤍 اللهم صل ِ وسلم على سيدنا محمد وعلى آله الطيبين الطاهرين شرح سلايدات المعمل الاول باثو ✨ #Endocrine_System #بلك_الغدد #قسم_العملي #اللجنة_العلمية_الدفعة_السادسة

#Microscopic #Diagnosis 👉🏻  Phenochromocytoma #The_black_arrow Phenochromocytoma والتي تظهر باللون البني عند صبغها بصبغة Chromogranin وتظهر الانوية باللون الازرق #The_blue_arrow Adrenal cortex (negative)

#Microscopic #Diagnosis 👉🏻  Phenochromocytoma #The_black_arrow Phenochromocytoma والتي تظهر باللون البني عند صبغها بصبغة S100 لانه ذي الصبغة تصبغ الادرينالين و النورادرينالين ويلي يكونوا في حاله افراز بشكل كبير #The_blue_arrow Adrenal cortex (negative)

سلايد اوضح Microscopic #Diagnosis 👉🏻   Phenochromocytoma #The_yellow_arrows intervening capillaries #The_black_arrows sustentacular cells #The_blue_area Zellballen ( nest )

#Microscopic #Diagnosis 👉🏻   Phenochromocytoma #The_black_star Neoplasm #The_black_arrows intervening capillaries #The_blue_arrow sustentacular cells #The_red_area Zellballen ( nest ) #The_yellow_arrows Vacuoles #The_blue_star Normal adrenal #The_features - Nested (zellballen) with adjacent smaller sustentacular cells surrounded by abundant intervening capillaries - Cells: large, polygonal to spindle , uniform or extensively vacuolated - Cytoplasm: abundant fine, granular red-purple cytoplasm - Nuclei: central round to oval, nucleoli prominent

#Gross #Diagnosis 👉🏻  Phenochromocytoma "chromaffin reaction" #The_red_arrow tumor which has not been placed in dichromate fixative #The_white_arrow tumor at the bottom has been placed into a dichromate fixative والذي يظهر لنا باللون البني الغامق وذلك عشان انه catecholamines حصلها oxidized

#Gross #Diagnosis 👉🏻  Phenochromocytoma #The_black_arrow Small remnant of remaining adrenal #The_white_star adrenal neoplasm #The_blue_arrow Hemorrhage #The_white_arrows Cortex #The_features - Well circumscribed and unencapsulated - Solid , gray tan - hemorrhagic in cut surface

#Microscopic #Diagnosis 👉🏻   Adrenocortecal carcinoma #The_black_star Invasion (Metastases to vein) #The_blue_arrow Hemorrhage #The_features - Encapsulated tumor  - Invasion of thick fibrous capsule - Lymphovascular invasion - hemorrhage - hyperchromic nuclei NOTES Often are functional and can lead to - Cushing diseas - Masculinization in females - Feminization in male

#Microscopic #Diagnosis 👉🏻  Adrenocortecal adenoma #The_red_arrow Adenoma #The_black_star Capsule of adenoma #The_blue_arrow Normal adrenal #The_blue_star Capsule of adrenal #The_features • adenoma cells are larger with different cytoplasm • increased variation in nuclear size • cells have abundant foamy cytoplasm like of zona fasciculata

#Gross #Diagnosis 👉🏻  Adrenocortical adenoma #The_white_arrow Adenoma #The_features - Circumscribed , Unilateral, solitary - yellow tan in color - Hemorrhage - Functional adenoma may result in atrophy of contralateral adrenal cortex NOTE Cause hypertension and hypokalemia

#Microscopic #Diagnosis 👉🏻  Adrenal nodular hyperplasia #The_black_arrows Nodules #The_blue_arrows Lipid poor pink cells like reticulari #The_red_arrows Lipid-rich clear cells like fasciculata NOTES - The Nodules larger than 3mm ( macronodular ) - metaplasia or atrophic cortex between nodules

#Gross A #Diagnosis 👉🏻  Atrophy adrenal gland DUE TO Addison’s disease or Long term using of Corticosteroids and stop using it suddenly not gradually B #Diagnosis 👉🏻 Normal adrenal gland • The cortex is yellow in color • The medulla is red in color C #Diagnosis 👉🏻 adrenal hyperplasia DUE TO Cushing's disease

#Microscopic #Diagnosis 👉🏻  Normal adrenal gland #The_red_star Periadrenal fat #The_black_star Capsule #The_blue_star Zona glomerulosa THE CELLS - well defined cells - Rounded - acidophilic cytoplasm - lipid droplets - secretes mineralocorticoids #The_yellow_star Zona fasiculata THE CELLS - Broad band of large cells with distinct membranes arranged in cords - Cytoplasm has numerous small lipid vacuoles - secretes glucocorticoids #The_green_star Zona reticularis THE CELLS - Granular and eosinophilic cytoplasm with minimal lipid - Richly vascularized, capsular blood vessels, nerves and lymphatics penetrate along connective tissue septae - secretes androgens #The_brown_star Medulla

#Gross #Diagnosis 👉🏻  Normal adrenal gland #The_black_arrow Normal right adrenal gland #The_white_arrow Adipose tissue #The_blue_arrow Kidney

#Microscopic #Diagnosis 👉🏻 Medullary carcinoma #The_blue_star Amyloid الذي يظهر لونها reddish بواسطة صبغة Congo red