JAMA (Journal of the American Medical Association)

Screening for Early-Stage Type 1 Diabetes in Children https://jamanetwork.com/journals/jama/fullarticle/2854198 To the Editor A recent article provided the first long-term evidence on presymptomatic type 1 diabetes prevalence and progression in the general pediatric population in Germany. Notably, the progression to clinical type 1 diabetes did not differ significantly based on first-degree family history. Based on their findings, the authors concluded that screening should be expanded “beyond genetically selected populations.” As an editorial in JAMA noted, these findings call for a broader screening approach than the latest American Diabetes Association guidelines, which recommend screening based on family history or genetic risk.

Diagnosis and Treatment of Patients With Primary Aldosteronism https://jamanetwork.com/journals/jama/fullarticle/2854199 This JAMA Insights discusses various aspects of primary aldosteronism, such as its epidemiology, diagnosis and screening, and treatment, including effective medication management.

Asymptomatic Carotid Revascularization May Be Justified, But Not to Improve Cognition https://jamanetwork.com/journals/jama/fullarticle/2854200 Stroke is a feared complication of atherosclerotic carotid artery stenosis. After years of debate regarding the value of revascularizing asymptomatic carotid stenosis in the modern era of intensive medical prevention with antiplatelet therapy and high-intensity statins, the CREST-2 trial revisited this question in a pair of randomized clinical trials: one trial comparing carotid endarterectomy plus best medical management vs medical therapy alone and the other comparing carotid artery stenting plus best medical management vs medial therapy alone. The topline findings showed that carotid artery stenting, but not carotid endarterectomy, significantly reduced the risk of the primary outcome of a composite of stroke or death within 44 days or ipsilateral stroke within up to 4 years compared with medical therapy alone among patients without contralateral stenosis who were good procedural candidates.

Revascularization in Asymptomatic Carotid Artery Stenosis With Hemodynamic Impairment and Cognitive Outcomes Research Summary https://jamanetwork.com/journals/jama/fullarticle/2854192 This study tested whether cognitive benefit from revascularization in asymptomatic high-grade internal carotid artery stenosis varied by baseline cerebral hemodynamic impairment.

The Maternal Mental Health Crisis https://jamanetwork.com/journals/jama/fullarticle/2854311 This Viewpoint discusses the maternal mental health crisis in the US, outlining gaps in care and assessing the preparedness of the system to handle severe acute perinatal psychiatric crises.

Caring Collectively Through Palliative Care Partnerships https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2853900 End-of-life cancer care represents a pivotal period for patients, families, and care providers. Palliative care consultation can enhance the quality of end-of-life care for patients with cancer, which has been demonstrated to be beneficial. The palliative care workforce, while growing, is still inadequate to meet patient care needs. Furthermore, the effectiveness of palliative care programs has been inconsistent in prior research, with some programs improving quality of life but not health care utilization. Specifically, hospice utilization varies widely despite the consistent presence of palliative care services in many oncology settings.

Administrative Bloat in Neurology and Academic Medicine https://jamanetwork.com/journals/jamaneurology/fullarticle/2854115 This Viewpoint describes the growth of administrative work across universities, health care, and research and suggests 5 questions a neurology department should ask about any administrative process.

Clinical Characteristics, Neuroimaging Findings, and Mortality in Korsakoff Syndrome https://jamanetwork.com/journals/jamaneurology/fullarticle/2854116 This cohort study of French adults diagnosed with Korsakoff syndrome identifies clinical features and outcomes of patients in routine clinical practice and examines factors associated with mortality.

IVIG in Idiopathic Inflammatory Myopathies https://jamanetwork.com/journals/jamaneurology/fullarticle/2854117 This randomized clinical trial evaluates the use of intravenous immune globulin as add-on treatment in newly diagnosed idiopathic inflammatory myopathy.

CAA-Like Brain Imaging and Dural AVF https://jamanetwork.com/journals/jamaneurology/fullarticle/2854118 This case report describes a patient in their 70s initially diagnosed with cerebral amyloid angiopathy whose diagnosis was challenged with repeat magnetic resonance imaging, which revealed arterialized left temporal cortical vein with an adjacent venous aneurysm.

Weight Loss in Older Adults With Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2854052 To the Editor In the LOSE-AF randomized clinical trial, a low-calorie diet and behavioral support program achieved significant weight loss but did not improve atrial fibrillation (AF) symptoms, AF burden, or subsequent rhythm-control outcomes in older patients with persistent AF. We believe an imbalance in baseline rhythm-control therapies may have affected the interpretation of these null findings.

Azithromycin for Cesarean Delivery https://jamanetwork.com/journals/jama/fullarticle/2854053 Preventing maternal morbidity and mortality remains an urgent global priority, yet progress has been unsatisfactory. Although maternal mortality has declined globally, the rates have increased in the US and infections are among the top causes of preventable deaths. Among women undergoing cesarean delivery (the most common major surgical procedure in the US), the risk of infection is many times higher than after vaginal delivery, underscoring the importance of effective prophylaxis.

Idiopathic Normal Pressure Hydrocephalus: A Review https://jamanetwork.com/journals/jama/fullarticle/2854046 This Review discusses the pathophysiology, epidemiology, risk factors, clinical presentation, diagnosis, treatment, and prognosis of idiopathic normal pressure hydrocephalus.

Error in Results https://jamanetwork.com/journals/jama/fullarticle/2854054 The Original Investigation titled “Gastric Residual Volume Assessment in Critically Ill Children: The GASTRIC-PICU Randomized Clinical Trial,” published on June 12, 2026, was corrected to update the number of participants in the usual care group in Figure 1 and P values for the intention-to-treat clinical co–primary outcome and per-protocol analysis in the Results section to be consistent with Table 2. This article was corrected online.

World Trade Center Exposure at 25 Years https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2853739 This Viewpoint discusses how clinicians can screen patients for exposure to the World Trade Center attacks on September 11, 2001.

Study Finds Artery Damage in Young Adults With CKM Syndrome https://jamanetwork.com/journals/jama/fullarticle/2854233 Cardiovascular-kidney-metabolic (CKM) syndrome is prevalent among young adults and is associated with greater signs of early artery damage, according to a study published in Circulation: Population Health and Outcomes. Nearly 80% of participants had CKM syndrome stages 1 to 3, which were linked to worse cardiovascular health.

Nicotine Vapes May Aid in Smoking Cessation https://jamanetwork.com/journals/jama/fullarticle/2854234 More people may quit smoking when using nicotine e-cigarettes, also known as vapes, compared with conventional nicotine replacement therapies (NRT) such as gum or patches and quitting with or without behavioral support, according to an updated Cochrane review.

Audio Highlights September 11, 2026 https://jamanetwork.com/journals/jama/fullarticle/2854237 Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.

Psilocybin https://jamanetwork.com/journals/jama/fullarticle/2853938 This JAMA Insights discusses the medical use of psilocybin, particularly for depression treatment, including emerging potential indications, safety, and future use.

Medicine’s Role in Mental Health Promotion https://jamanetwork.com/journals/jama/fullarticle/2853937 Dana L. Farnsworth, M.D., Cambridge, Mass.