𝒔𝒂𝒕𝒊𝒔𝒇𝒂𝒄𝒕𝒐𝒓𝒚 𝒂𝒏𝒂𝒍𝒚𝒛𝒆𝒔🔩

🔴محاضرة Behcet's Disease 🔵هذا المرض يصيب الرجال Men 🔸characterized by a triad of symptoms, including 🔹aphthous ulceration of the oral 🔹mucous membranes 🔹genitalia and uveitis 🔸Rare manifestations include 🔹oligoarthritis of the lower extremities 🔹vasculitis of the pulmonary vessels 🔹cerebrovascular symptoms 🔸Behcet's Disease associated with 🔹HLA B51 🔸Behcet's disease may cause inflammation called uveitis that means: 🔹Inflammation in the eyes 🔸Risk factors 🔹Age 🔹Geography 🔹Sex 🔹Genes 🔴مستويات التاليه كلها مرتفعه في مرض بهجت 🔹C-reactive protein levels 🔹erythrocyte sedimentation rate (ESR) 🔹leukocyte count 🔹complement components 🔸International Clinical Criteria for Behcet's Disease المعاییر السریریة الدولیة لمرض بھجت 🔹Recurrent oral ulcerations (apthous or herpetiform) 🔹Recurrent genital ulcerations 🔹Eye lesions (uveitis or retinal vasculitis 🔹Skin lesions (rashes or acne-like sores) 🔹Positive pathergy test

محاضره Ankylosing spondylitis اسماء الاخرى 🔹spondyloarthritis (SpA) 🔹spondyloarthropathy 🔸Ankylosing spondylitis is an inflammatory disease that usually affects: 🔹Spine 🔸is more commonly affected by ankylosing spondylitis 🔹Men الرجال 🔸blood test which is used to assess the tendency to develop ankylosing spondylitis 🔹(HLA)-B27 🔴A physical examinationthe Schober's test مرضئ الذين يعانون من AS يرتفع كل من 👇 🔹elevated levels of IgA 🔹elevated erythrocyte 🔹sedimentation rates 🔹C-reactive protein 🔵 بشكل شائع يرتفع ESR RF and ANA 👉👉👉negative ____________________________________ 🔸Psoriatic Arthritis 🔹characterized by osteolysis and bony proliferation يصيب الرجال ونساء 🔹Males and females are equally RF and ACPA 👉👉👉negative 🔴ايضا في هذا المرض ESR مرتفع Clinical manifestations include 🔹skin and nail psoriasis 🔹dactylitis 🔹enthesitis 🔹osteoperiostitis 🔹large joint oligoarthritis 🔹arthritis mutilans 🔹sacroiliitis 🔹spondylitis 🔹distal interphalangeal arthritis العوامل مصاحبه لمرضى التهاب المفاصل الصدفي Comorbidities in PsA PatientsPSA 🔹Ocular inflammation (Iritis Uveitis/ Episcleritis) 🔹Irritable bowel disease (IBD) 🔹Metabolic Syndrome (Hyperlipidemia, Hypertension, Insulin resistant , Diabetes ,Obesity ) lead to Higher risk of Cardiovascular disease (CVD) 🔹Psychosocial burden, Reactive depression, Higher suicidal ideation and Alcoholism

🔴محاضرة SLE 🔸age do symptoms of SLE usually appear 🔹Between age 15 and 25 years 🔸The most specific and diagnostic autoantibody in SLE is 🔹Anti-dsDNA 🔸The highest predisposing gene for the incidence of SLE is: 🔹HLA DR3/DR2 🔸factors are associated with its development SLE : 🔹Genetic (HLA-DR2/DR3) Racial, and hormonal Immune abnormalities and environmental factors 🔸is the most specific and sensitive test for (SLE)? 🔹Antinuclear antibody (ANA) 🔸ratio of female to male cases of SLE? 🔹9 to 1 🔸Extractable nuclear antigens (ENA) include 🔹1-Sm (Smith) 🔹2-RNP(ribonucleoprotein) 🔹3-Ro (Robert) called SS-A 🔹4-La (Lane) called SS-B 🔹anti- Jo-1, anti Scl-70 and anticentromere, 🔸protein is specific for SLE 🔹Sm (Smith) 🔵جدول محاضرة الاولى مهم

🔴محاضرة RA 🔸RA onset usually occur 🔹Between ages of 35-60 years 🔸is the main genetic risk factor for RA 🔹HLA-DR4 / HLA-DR1 🔸is the sex predilection ratio of RA 🔹Women: Men - 3:1 🔸is the most specific test for RA 🔹anti-CCP 🔸test is not very specific of Rheumatoid Arthritis 🔹Rheumatoid factor ( RF ) 🔸is elevated in approximately 90% of patient with RA 🔹ESR 🔸approximately 30% of patient with RAThis test is not routinely 🔹ANA 🔸test can be used to aid in the diagnosis of Rheumatoid arthritis: 🔹Anti-cyclic citrullinated peptide 🔹Rheumatoid factor 🔹ESR 🔹Blood test

SLE 9 : 1 SS 9 : 1 PBS 9 : 1 النساء ٩ والرجال ١ كلهم Grave. 7 : 1 Hashmotoo . 4 : 1 امراض الغدة الدرقية النساء اكثر PA فقر دم خبيث . Equaly = PSA الصدفية . Equaly = Cron مرض كرون . Equaly = Behcet مرض بهجت من اسمه الرجال اكثر من النساء PSC الرجال اكثر من النساء RA. 3 : 1 النساء اكثر AS . 3 : 1 الرجال اكثر

كلششش راح يفيدكم🔥

C ANCA = PR3 pANCA = MPO ..........................

يفيدكم مناعه❤️

طلاب هذا الملخص لكيته بقنوات العام الماضي ،الي هو عن محاضرة الربو يختصر شلون نقرا الانترلوكينات 😢

Double strand dNA ——> specific ANA——> sensitive ب SLE

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