3 898
订阅者
无数据24 小时
-127 天
-1530 天
数据加载中...
吸引订阅者
四月 '26
四月 '26
+20
在0个频道中
三月 '26
+29
在0个频道中
Get PRO
二月 '26
+29
在1个频道中
Get PRO
一月 '26
+43
在0个频道中
Get PRO
十二月 '25
+34
在0个频道中
Get PRO
十一月 '25
+10
在0个频道中
Get PRO
十月 '25
+6
在0个频道中
Get PRO
九月 '25
+4
在0个频道中
Get PRO
八月 '25
+16
在0个频道中
Get PRO
七月 '25
+4
在0个频道中
Get PRO
六月 '25
+9
在1个频道中
Get PRO
五月 '25
+3
在1个频道中
Get PRO
四月 '25
+7
在0个频道中
Get PRO
三月 '25
+12
在0个频道中
Get PRO
二月 '25
+5
在0个频道中
Get PRO
一月 '25
+5
在0个频道中
Get PRO
十二月 '24
+5
在0个频道中
Get PRO
十一月 '24
+44
在0个频道中
Get PRO
十月 '24
+34
在0个频道中
Get PRO
九月 '24
+35
在0个频道中
Get PRO
八月 '24
+51
在0个频道中
Get PRO
七月 '24
+84
在1个频道中
Get PRO
六月 '24
+100
在1个频道中
Get PRO
五月 '24
+76
在1个频道中
Get PRO
四月 '24
+82
在0个频道中
Get PRO
三月 '24
+69
在0个频道中
Get PRO
二月 '24
+53
在1个频道中
Get PRO
一月 '24
+116
在2个频道中
Get PRO
十二月 '23
+48
在0个频道中
Get PRO
十一月 '23
+77
在1个频道中
Get PRO
十月 '23
+74
在1个频道中
Get PRO
九月 '23
+58
在0个频道中
Get PRO
八月 '23
+47
在0个频道中
Get PRO
七月 '23
+45
在0个频道中
Get PRO
六月 '23
+36
在0个频道中
Get PRO
五月 '23
+45
在0个频道中
Get PRO
四月 '23
+32
在0个频道中
Get PRO
三月 '23
+30
在0个频道中
Get PRO
二月 '23
+103
在0个频道中
Get PRO
一月 '23
+58
在0个频道中
Get PRO
十二月 '22
+60
在0个频道中
Get PRO
十一月 '22
+63
在0个频道中
Get PRO
十月 '22
+49
在0个频道中
Get PRO
九月 '22
+60
在0个频道中
Get PRO
八月 '22
+57
在0个频道中
Get PRO
七月 '22
+50
在0个频道中
Get PRO
六月 '22
+72
在0个频道中
Get PRO
五月 '22
+72
在0个频道中
Get PRO
四月 '22
+71
在0个频道中
Get PRO
三月 '22
+57
在0个频道中
Get PRO
二月 '22
+62
在0个频道中
Get PRO
一月 '22
+73
在0个频道中
Get PRO
十二月 '21
+39
在0个频道中
Get PRO
十一月 '21
+50
在0个频道中
Get PRO
十月 '21
+63
在0个频道中
Get PRO
九月 '21
+62
在0个频道中
Get PRO
八月 '21
+58
在0个频道中
Get PRO
七月 '21
+57
在0个频道中
Get PRO
六月 '21
+62
在0个频道中
Get PRO
五月 '21
+66
在0个频道中
Get PRO
四月 '21
+67
在0个频道中
Get PRO
三月 '21
+76
在0个频道中
Get PRO
二月 '21
+66
在0个频道中
Get PRO
一月 '21
+166
在0个频道中
Get PRO
十二月 '20
+2 912
在0个频道中
| 日期 | 订阅者增长 | 提及 | 频道 | |
| 26 四月 | +1 | |||
| 25 四月 | 0 | |||
| 24 四月 | +1 | |||
| 23 四月 | 0 | |||
| 22 四月 | +1 | |||
| 21 四月 | 0 | |||
| 20 四月 | +2 | |||
| 19 四月 | +1 | |||
| 18 四月 | 0 | |||
| 17 四月 | +2 | |||
| 16 四月 | +1 | |||
| 15 四月 | 0 | |||
| 14 四月 | 0 | |||
| 13 四月 | 0 | |||
| 12 四月 | +2 | |||
| 11 四月 | 0 | |||
| 10 四月 | +1 | |||
| 09 四月 | 0 | |||
| 08 四月 | 0 | |||
| 07 四月 | 0 | |||
| 06 四月 | +1 | |||
| 05 四月 | +2 | |||
| 04 四月 | +2 | |||
| 03 四月 | +1 | |||
| 02 四月 | +2 | |||
| 01 四月 | 0 |
频道帖子
Infants born to mothers with hyperparathyroidism often develop transient hypoparathyroidism, resulting in hypocalcemia and
hyperphosphatemia
| 2 | The characteristic chest x-ray findings in
infants with respiratory distress syndrome
include reduced lung volumes, air bronchograms, reticulogranularity, and lung opacification. The x-ray appearance is frequently
characterized as having a homogenous ground
glass appearance. | 0 |
| 3 | The newborn with cystic fibrosis generally
is asymptomatic. The most common manifestation, meconium ileus, occurs in 15%–20% of
CF patients. The ileum is completely obstructed
with meconium, which results in intestinal
obstruction. The meconium plug syndrome
also is seen with an increased frequency in
infants with cystic fibrosis, but it is less specific
than meconium ileus. Sweat chloride testing
in suspected cases of cystic fibrosis has always
been troublesome in the newborn period but
DNA testing is now available and is 90%–95%
sensitive. In the United States, some states have
instituted routine newborn screening for cystic
fibrosis. | 0 |
| 4 | Beckwith-Wiedemann
syndrome
:
omphalocele,
severe hypoglycemia,
macrosomia,
macroglossia | 0 |
| 5 | Fever + Petechial/purpuric rash + shock + rapid progressive GCS low = meningococcemia
So do immediately→ blood culture + immediate IV antibiotics | 0 |
| 6 | Osteogenesis Imperfecta (OI) :
“Brittle bone disease”
A genetic disorder of connective tissue characterized by bone fragility due to defective type I collagen.
Etiology
• Mostly autosomal dominant
• Mutations in COL1A1 / COL1A2 genes
• Leads to ↓ quantity or abnormal quality of type I collagen
⸻
Classic Clinical Features
Mnemonic: B L U E
• Bones fracture easily (minimal trauma)
• Ligament laxity & joint hypermobility
• Unusually blue sclera
• Ear problems → hearing loss (conductive/sensorineural)
Other features
• Short stature
• Bone deformities
• Scoliosis
• Dentinogenesis imperfecta (opalescent teeth)
• Wormian bones in skull (X-ray)
⸻
Sillence Classification (Simplified)
Type Severity Key Features
Type I Mild Blue sclera, normal stature, fractures in childhood
Type II Lethal Multiple fractures at birth, severe deformities
Type III Severe Progressive deformity, very short stature
Type IV Moderate Normal sclera, fractures, mild deformity
⸻
Diagnosis
• Clinical features + family history
• X-ray: osteopenia, fractures, Wormian bones
• Genetic testing (confirmatory)
• DEXA scan → low bone density
⸻
Management
• No cure → supportive & preventive
• Bisphosphonates (e.g., pamidronate) ↓ fracture rate
• Calcium & Vitamin D
• Physiotherapy
• Orthopedic surgery (rodding)
• Hearing evaluation
• Genetic counseling
⸻
Key Exam Pearls
• Blue sclera + recurrent fractures → think OI
• Differentiate from child abuse
• Normal calcium, phosphate, ALP usually | 0 |
| 7 | Kartagener Syndrome (KS) :
Kartagener syndrome is a subset of Primary Ciliary Dyskinesia (PCD) characterized by the triad of:
1. Chronic sinusitis
2. Bronchiectasis
3. Situs inversus
It is a genetic disorder of motile cilia leading to impaired mucociliary clearance.
⸻
🧬 Etiology & Genetics
• Autosomal recessive
• Caused by defects in dynein arms of cilia
• Common genes: DNAH5, DNAI1
• Leads to immotile or dyskinetic cilia
⸻
🔬 Pathophysiology
Defective ciliary movement →
• Poor clearance of mucus and pathogens →
• Recurrent respiratory infections
• During embryogenesis, impaired ciliary motion causes random organ placement → situs inversus
⸻
🧑⚕️ Clinical Features
Respiratory
• Chronic productive cough
• Recurrent pneumonia
• Bronchiectasis
• Chronic rhinosinusitis
• Otitis media → hearing loss
Laterality
• Situs inversus totalis (heart on right, liver on left)
Reproductive
• Male infertility (immotile sperm flagella)
• Reduced female fertility (impaired ciliary transport in fallopian tubes)
Neonatal Period (important!)
• Unexplained neonatal respiratory distress in term infants
⸻
🧪 Diagnosis
Screening / Clues
• Chronic wet cough from early childhood
• Recurrent ENT + chest infections
• Dextrocardia on chest X-ray
Confirmatory Tests
• Low nasal nitric oxide (screening)
• High-speed video microscopy – abnormal ciliary motion
• Electron microscopy – absent dynein arms
• Genetic testing (confirmatory)
⸻
🧠 Key Differentiation
Feature Kartagener Syndrome Cystic Fibrosis
Situs inversus ✅ Yes ❌ No
Sweat chloride Normal Elevated
Fertility issues Common Less common
Cause Ciliary dysfunction CFTR mutation
⸻
🩺 Management
There is no cure, but symptoms are manageable:
• Chest physiotherapy
• Regular airway clearance
• Prompt antibiotics for infections
• Vaccinations (influenza, pneumococcal)
• ENT care (grommets if needed)
• Fertility counseling in adults
⸻
📌 Exam Pearl (MRCPCH / USMLE)
Chronic sinusitis + bronchiectasis + situs inversus = Kartagener syndrome until proven otherwise | 0 |
| 8 | Indications for MRI of brain.
1.Focal epilepsy (including TLE) except rolandic seizures.
2. Epilepsy in children aged <2 yr •
3.Myoclonic epilepsy.
4.Intractable seizures.
5.Loss of previous good control.
6.Seizures continuing in spite of first line medication.
7.Associated neurological deficits.
8.appearance of new neurological signs •
9.Developmental regression in children with epilepsy.
10.Infantile spasms (West’s syndrome) | 0 |
| 9 | #note
Causes of《 Apnea》In Premature Baby》:
🌕Hyaline Membrane disease
🌕Hypoglycemia
🌕Narcotic Drug Given To Mother
🌕Intracranial haemorrhage
🌕Pneumonia
🌕Sepsis | 0 |
| 10 | 🔘Acute Bronchiolitis In Infancy :🔻
⛔Cause:
Respiratory syncytial virus (RSV)
⛔Clinical/Picture:
◽Cough
◽Wheeze
◽Dyspnea
◽⬇ Feeding
◽Apnea
◽Tachypnea
⛔-Treatment
◽ O2
◽IVF
⛔Death causes:
◽Respiratory failure
◽Apnea
◽Dehydration | 0 |
| 11 | 📌Lung Cancer :-
💡The most common cause of bronchial cancer is cigarette smoking.
💡The most common type of lung cancer is adenocarcinoma.
💡The least common type of lung cancer is large cell carcinoma.
💡The most common worst type of lung cancer is mainly mesothelioma (2_3 months survival rate) and small cell carcinoma (1_2 years survival rate).
💡The most common early symptom is dry cough.
💡The most common lung cancer causing superior vena cava syndrome is small cell lung carcinoma (SCLC).
💡The most common lung cancer causing pancoast tumor is squamous cell carcinoma.
💡The most common lung cancer causing SIADH is small cell carcinoma (due to secretion of ADH).
💡The most common lung cancer causing hypercalcemia is squamous cell carcinoma (due to secretion of PTH_like protein).
💡The most common lung cancer causing cushing's syndrome is small cell carcinoma (due to secretion of ectopic ACTH).
💡The most common lung cancer causing eaton_lambert syndrome is small cell carcinoma.
💡The most common lung cancer causing hypertrophic osteoarthropathy is adenocarcinoma.
💡The most common lung cancer causing gynecomastia and galactorrhoea in males and false positive pregnancy test in females is large cell carcinoma (due to secretion of beta_HCG).
💡The most specific investigation is biopsy.
💡The most useful initial test is CXR.
💡The most common type of lung cancer in non_smoker is adenocarcinoma.
💡The most common cavitating lung cancer is squamous cell carcinoma.
💡The most sensitive lung cancer to radiotherapy and chemotherapy is small cell lung carcinoma.
💡The least sensitive lung cancer to radiotherapy and chemotherapy is large cell carcinoma.
💡The best prognostic tumor among lung cancers is squamous cell carcinoma. | 0 |
| 12 | Evidence of fat malabsorption —
such as:
Steatorrhoea
Deficiencies of fat-soluble vitamins (A, D, E, K)
👉 usually points more towards Crohn’s disease (CD) than Ulcerative colitis (UC).
🔹 Reason:
In Crohn’s disease, the small intestine (especially the terminal ileum) is often involved → this is where fat and fat-soluble vitamins are absorbed → leading to malabsorption.
In Ulcerative colitis, the disease is confined to the colon → nutrient absorption in the small bowel is preserved → steatorrhoea and vitamin deficiencies are uncommon.
📌 So, the presence of fat malabsorption is a clinical clue favouring CD over UC
@clinicalnote | 0 |
| 13 | Ascites in an elderly patient without liver disease →
you should think beyond cirrhosis/portal hypertension.
Here are the major alternative causes:
🔹 1. Malignancy (common in old age)
Peritoneal carcinomatosis (ovarian, gastric, colon, pancreatic, breast cancers).
Malignant ascites is often high protein and usually has a low SAAG (<1.1 g/dL).
🔹 2. Heart failure / Constrictive pericarditis
Right heart failure, tricuspid regurgitation.
Ascitic fluid: high SAAG (>1.1 g/dL) and high protein.
🔹 3. Nephrotic syndrome
Hypoalbuminemia → reduced oncotic pressure.
Ascitic fluid: low SAAG (<1.1), low protein.
🔹 4. Tuberculosis peritonitis
Chronic ascites, often with fever, night sweats, weight loss.
Ascitic fluid: exudative, lymphocyte-predominant, high ADA.
🔹 5. Pancreatic or Biliary disease
Pancreatic ascites (chronic pancreatitis, duct leak).
Biliary ascites (bile leak after trauma/surgery).
Ascitic fluid:
very high amylase (pancreatic), or high bilirubin (biliary).
📌 Approach:
Always calculate SAAG (serum–ascites albumin gradient):
≥ 1.1 g/dL → portal hypertension (cardiac, hepatic, Budd–Chiari).
< 1.1 g/dL → peritoneal cause (malignancy, TB, pancreatitis, nephrotic syndrome).
@clinicalnote | 0 |
| 14 | Syndrome Triad
Murmur (pulmonary stenosis) + Jaundice + Butterfly vertebrae=Alagille syndrome
Wilms tumor + Aniridia + Genitourinary anomalies=WAGR syndrome
Macrosomia + Macroglossia + Omphalocele / Umbilical hernia=Beckwith-Wiedemann (BWS)
Coloboma + Heart defect + Choanal atresia=CHARGE syndrome
Situs inversus + Chronic sinusitis + Bronchiectasis=Kartagener syndrome
Micrognathia + Glossoptosis + Cleft palate=Pierre-Robin sequence
Mandibular hypoplasia + Coloboma of lower eyelid + Ear anomalies=Treacher-Collins syndrome
Pancytopenia + Short stature + Skeletal anomalies=Fanconi anemia
Pure red cell aplasia + Craniofacial anomalies + Thumb anomalies=Diamond-Blackfan anemia
Dark urine + Arthritis + Pigmentation (ochronosis)=Alkaptonuria
Mandibular hypoplasia + Limb anomalies + Ear anomalies=Nager syndrome
Facial port-wine stain + Leptomeningeal angioma + Seizures=
Sturge-Weber syndrome
Facial asymmetry + Epibulbar dermoid + Vertebral anomalies
=Goldenhar syndrome
Hypotonia + Single palmar crease + Characteristic facies=Trisomy 21 (Down)
Hypotonia + Hyperphagia / Obesity + Developmental delay= Prader-Willi syndrome
Severe developmental delay + Happy demeanor / laughter + Ataxia / seizures =Angelman syndrome
@clinicalnote | 0 |
| 15 | Noonan syndrome:
Pulmonary stenosis + Short stature + Facial features | 0 |
| 16 | Beckwith-Wiedemann syndrome (BWS)
Macrosomia + Macroglossia + Omphalocele / umbilical hernia | 0 |
| 17 | Biliary atresia syndromic
Jaundice + Polysplenia + CHD | 0 |
| 18 | #Keypoint:#The_most_common .
#The most common cause of
Acute bronchiolitis --RSV .
CROUP -------------parainfluenza V.
Septic arthritis ------staph aureus.
Subacute IE ---------strep viridans .
# The most common malignancy in pediatrics is leukemia.(most common type ALL)
# The most common solid tumor in pediatrics is brain tumors.
# The most common extracranial solid tumor in pediatrics is neuroblastoma.
# The most common vasculitis in pediatrics is Henoch Schonlein purpura.).
# The most common cause of acute renal failure in pediatrics(UK) is haemolytic uraemic syndrome,
---but in developing countries is dehydration..
# The most common cause of haemolytic uraemic syndrome is Shiga toxin producing E Coli.
# The most common inherited bleeding tendency is Von Willebrand disease.
# The most common cause of hypertension in pediatrics is secondary to renal disease.
# The most common cause of acute flaccid paralysis in childhood is Guillain Barre syndrome.
#the most common trisomy and the most common genetic cause of severe learning difficulties is Down syndrome.
# The most common congenital heart disease is ventricular septal defect.
# The most common congenital heart disease in patients with Down's syndrome is atrioventricular canal.
# The most common mutation causing cystic fibrosis is delta F 508.
# The most common #skeletal anomaly in infant of diabetic mother is sacral agenesis . | 0 |
| 19 | NF1 + café-au-lait + heart murmur (pulmonary stenosis) → Watson syndrome
NF1 classic: multiple café-au-lait, axillary freckling, Lisch nodules, neurofibromas.
McCune-Albright: unilateral/irregular café-au-lait + endocrine problems, no heart murmur.
NF2: focus on bilateral vestibular schwannomas, not skin lesions. | 0 |
| 20 | Ambigous genitalia
We have to send for RBS and serum potassium, to exclude tge possibility of congenital adrenal hyperplasia CAH.
#pediatric | 0 |
