Oncology

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Correct Answer- A Ans. is 'a i.e., CD 117 Immunohistochemistry ◦ Following markers are present in GISTs: CD 117 (c kit) ->95% D I i) CD 34 70% iii) Smooth muscle actin 5% . CD 117 (c kit) is considered the most specific marker ○ CD 117 (c kit) immunoreactivity is the best defining feature of GISTs distinguishing them from true smooth muscle tumors (leiomyoma) and tumors arising from neural crest. ○ Although CD 117 (c kit) is considered the most specific marker for GIST, it is not pathognomonic of GIST as other tumors may also express CD 117. These tumors include mast cell tumor, germ cell tumors (seminomas), leukemias, malignant melanoma, angiolipomas, and some sarcomas

Correct Answer-B Scans to differentiate adrenal adenoma from adrenal metastasis are: .CECT • Chemical shift MRI .FDG-PET PETscan has almost 100 % sensitivity for detecting adrenal metastasis. so a negative study excludes the possibility of adrenal mets. But adenomas can give false positive test. Ref: Fundamentals of Diagnostic Radiology, Edition - 4, Page - 427

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Correct Answer B Amongst the options provided, gastrinomas are the most common enteropancreatic tumors associated with MEN I with insulinomas being the second most common. Ref: Harison's Principles of Internal Medicine, 17th Edition, Page 2358 & 2359; 16th/ 2232; Davidson's principles and practice of Medicine, 20th Edition, Chapter 20, Page 803

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Correct Answer - D Answer- D. 80% Solitary adenomas, A single abnormal gland, is the cause in -80% of patients; the abnormality in the gland is usually a benign neoplasm or adenoma and rarely a parathyroid carcinoma.

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