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What is the mechanism of action of Chloramphenicol in inhibiting protein synthesis?
a. Binding irreversibly to the 50S ribosomal subunit
b. Binding to the 30S ribosomal subunit
c. Inhibiting the translocation steps of protein synthesis
d. Blocking elongation of protein synthesis
Which adverse effect is associated with Macrolides and Ketolides in terms of prolonging the QTc interval?
a. Anemias
b. Ototoxicity
c. Cholestatic jaundice
d. QTc prolongation
How do Aminoglycosides (AGs) inhibit protein synthesis?
a. Binding to the 50S ribosomal subunit
b. Binding to the A-site on the 16S ribosomal RNA
c. Inhibiting the peptidyl transferase reaction
d. Blocking elongation of protein synthesis
What is the most commonly encountered naturally occurring resistance to Tetracyclines (TCs)?
a. Enzymatic inactivation of the drug
b. Production of bacterial proteins that prevent TCs from binding to the ribosome
c. Efflux pump that expels drug out of the cell
d. Decreased uptake of the antibiotic
5. Which antibiotic is known for causing "gray baby syndrome"?
a. Aminoglycosides
b. Tetracyclines
c. Chloramphenicol
d. Macrolides
4. What is the primary mechanism of resistance to macrolides?
a. Decreased uptake of the antibiotic
b. Efflux pumps expelling the drug
c. Enzymatic inactivation of the drug
d. Binding of the drug to ribosomal subunits
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