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O'zMU Biologiya fakulteti Biokimyo kafedrasidagi "Yosh biokimyogarlar" to'garagi 22-23 http://t.me/Yosh_biokimyogar_bot 🔬 Mazkur kanalda: 🧪Yosh biokimyogarlar to'garagining vaqti, kuni va mavzusi; 🧬 Ilm-fan:🎓PhD, magistr va bakalavrlar u-n yangiliklar
إظهار المزيد- المشتركون
- التغطية البريدية
- ER - نسبة المشاركة
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جاري تحميل البيانات...
Plant-based edible vaccines that provide two-layered protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outweigh the currently used parenteral types of vaccines, which predominantly cause a systemic immune response. Here, we engineered and selected a transgenic tomato genotype (TOMAVAC) that stably synthesized an antigenic S1 protein of SARS-CoV-2. Two-course spaced force-feeding of mice with ≈5.4 μg/ml TOMAVAC increased up to 16-fold the synthesis of RBD-specific NAbs in blood serum and the significant induction of S-IgA in intestinal lavage fluid. In a surrogate virus neutralization test, TOMAVAC-induced NAbs had 15–25% viral neutralizing activity. The results suggested early evidence of the immunogenicity and protectivity of TOMAVAC against the coronavirus disease 2019 (COVID-19) infection. Furthermore, we observed a positive trend of statistically significant 1.2-fold (average of +42.28 BAU/ml) weekly increase in NAbs in the volunteers' serum relative to the initial day. No severe…
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