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Answer2885. #EXPLANATION GOALS OF JSSK ARE: ⦁ To reduce out –of-pocket expenses related to maternal and new-born care. ⦁ The scheme implemented across the country entitles all pregnant woman delivering in public health institutions to absolutely free and no expense normal delivery (3 days), including caesarean section (7 days). ⦁ Similar entitlements are in place for all sick new-born (first 30 days of life) accessing public health institutions for treatment. ⦁ Free assured transport (ambulance service) from home to health facility, inter-facility transfer in case of referral and drop back is an entitlement Ans. B. JSSK (Janani-Shishu Suraksha Karyakram)
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Answer2884. #EXPLANATION ⦁ The few symptoms of the bite include: tightening of the facial muscles in one to two hours of the bite; inability of the bite victim to see or talk, and, if left untreated, the patient may die from respiratory paralysis within four to five hours. ⦁ A clinical toxicology study gives an untreated mortality rate of 70-80% Ans. C. Krait bite
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Answer2883. #EXPLANATION ⦁ Indinavir is a protease inhibitor AND olanzapine is an atypical antipsychotic, both cause metabolic syndrome like hyperlipidemia and central obesity Ans. D. Both B and C
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Answer2881. #EXPLANATION ⦁ Hyponatremia and inability to form dilute urine in the fully hydrated condition with concomitant lung cancer points to suspicion of SIADH. ⦁ Antagonists of ADH are used to treat SIADH. Tolvaptan - ⦁ It is a direct ADH receptor antagonist. ⦁ It is used for the correction of water retention and hyponatremia occurring in syndrome of inappropriate ADH secretion (SIADH) as well as in advanced CHF. ⦁ In clinical trials on CHF patients with hyponatremia - Tolvaptan has afforded short-term improvement by increasing water excretion, restoring serum Na· and relieving dyspnoea. Ans. D. Tolvaptan
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Answer2882. #EXPLANATION ⦁ Epidemic typhus (classical typhus fever, or louse-borne typhus) has disappeared from most areas of the world but might reappear in conditions of famine, war, or other disasters. There are small areas where it is endemic. ⦁ The responsible organism, a rickettsia, is conveyed from case to case by the human body louse, P. humanus corporis. Malaria, in its various forms (Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae), is spread from human to human by females of the various Anopheles group of mosquitoes. ⦁ Dengue fever has a worldwide distribution in tropical and subtropical areas. In addition to producing the classical fever with severe myalgia (breakbone fever), it can also cause a hemorrhagic fever. ⦁ The causative agent, a group B arbovirus with four distinct serogroups, is virus-conveyed from case to case by the A. aegypti mosquito. Colorado tick fever occurs mainly in mountainous areas of the United States within the range of its vector, D. andersoni. ⦁ The highest incidence is in May and June. Several hundred cases are recorded annually, but it is likely that the actual incidence is much higher. Avoidance of tick bites is the principal control measure. ⦁ Yellow fever, the prototypical viral hemorrhagic fever, is African in origin but has spread to and remains endemic in equatorial regions of Central and South America. The vector, A. aegypti, has also spread worldwide, but surprisingly, cases have not been reported in India and Southeast Asia. ⦁ The illness varies in severity from a mild, nonspecific fever to a more severe condition with hemorrhagic, hepatic, and renal manifestations. Ans. C. Pediculus humanus corporis
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Answer2880. #EXPLANATION ⦁ 201 IPC - causing disappearance of evidence of offence. ⦁ 202 IPC - intentional omission to give information of offence by a person bound to inform. ⦁ 203 IPC - giving false information respecting the offence committed ⦁ 176 IPC - omission to give information to public servant by person legally bound to give. ⦁ Difference between 202 IPC & 176 IPC is, in 202 IPC the person who is bound to give information knows that the act is an offence & knowing that it's an offence still he does not give info to concerned authority ⦁ Whereas 176 IPC is information on any subject Ans. B. 202 IPC
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Answer2879. #EXPLANATION ⦁ Brain natriuretic peptide (BNP), now known as B-type natriuretic peptide or Ventricular Natriuretic Peptide (still BNP), is a 32-amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes). ⦁ The release of BNP is modulated by calcium ions. ⦁ BNP is named as such because it was originally identified in extracts of porcine brain, although in humans it is produced mainly in the cardiac ventricles. ⦁ Some myocytes located within the atrium have specific granules that are the storage sites for atrial natriuretic peptide (ANP). The actions of ANP include natriuresis, diuresis, and vasodilation. ANP is increased in patients with hypertension and congestive heart failure. In the latter it may counteract the effects of the renin-angiotensin- aldosterone (RAA) and sympathetic systems. B-type natriuretic peptide levels are sensitive and specific markers of congestive heart failure and serial measurements may help in the clinical management of congestive heart failure. ⦁ The main clinical utility of either BNP or NT-proBNP is that a normal level rules out acute heart failure in the emergency setting. An elevated BNP should never be used to "rule in" acute or heart failure in the emergency setting due to lack of specificity. ⦁ BNP can also be used for screening and prognosis of heart failure. ⦁ The physiologic actions of BNP are similar to those of ANP and include decrease in systemic vascular resistance and central venous pressure as well as an increase in natriuresis. ⦁ Thus, the net effect of BNP and ANP is a decrease in blood volume, which lowers systemic blood pressure and afterload, yielding an increase in cardiac output, partly due to a higher ejection fraction. Ans. B. B-type natriuretic peptide (BNP)
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Answer2878. #EXPLANATION ⦁ 88 IPC - nothing is an offence done in good faith & for benefit of the patient, with consent from the patient, even if causes complications. ⦁ 89 IPC - In case of a child below 12yrs & an insane person, consent of guardian is must. ⦁ 90 IPC - consent given by a child under 12yrs or by an insane person or under fear or fraud, is an invalid consent. ⦁ 92 IPC - act done in good faith and for the benefit of the patient, even without consent, if the circumstances are such that it is impossible to obtain consent either from patient or his guardians in time, is not offence. Ans. D. Sec 92 IPC
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Answer2876. #EXPLANATION ⦁ The most widely used method for determining the purity of a protein is SDS-PAGE— polyacrylamide gel electrophoresis (PAGE) in the presence of the anionic detergent sodium dodecyl sulfate (SDS). ⦁ Electrophoresis separates charged biomolecules based on the rates at which they migrate in an applied electrical field. ⦁ For SDS-PAGE, acrylamide is polymerized and crosslinked to form a porous matrix. ⦁ SDS denatures and binds to proteins at a ratio of one molecule of SDS per two peptide bonds. When used in conjunction with 2-mercaptoethanol or dithiothreitol to reduce and break disulfide bonds, SDS separates the Component polypeptides of multimeric proteins. ⦁ The large number of anionic SDS molecules, each bearing a charge of −1, on each polypeptide overwhelms the charge contributions of the amino acid functional groups. ⦁ Since the charge-to-mass ratio of each SDS polypeptide complex is approximately equal, the physical resistance each peptide encounters as it moves through the acrylamide matrix determines the rate of migration. ⦁ Since large complexes encounter greater resistance, polypeptides separate based on their relative molecular mass (Mr). ⦁ Individual polypeptides trapped in the acrylamide gel are visualized by staining with dyes such as Coomassie blue. Ans. C. It is a dimer containing two 20kd and two 30kd
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Answer2877. #EXPLANATION ⦁ Physiological antagonism: ⦁ The effect produced by two drugs is opposite and the receptors on which these drugs acts also are different. ⦁ For example adrenaline acts on beta 2 receptor and causes bronchodilation and histamine acts on H1 receptor and cause bronchoconstriction ⦁ Other examples: glucagon increases glucose and insulin decreases glucose by different receptors ⦁ Physical antagonism: ⦁ Charcoal antagonizing poisons by adsorption ⦁ Chemical antagonism: ⦁ The chemical reaction between two drugs cause antagonism ⦁ Example: HCl+ antacids, heparin+ protamine sulfate Ans. D. Physiological antagonism
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Answer2875. #EXPLANATION ⦁ Important inhibitory neurotransmitters in the gastrointestinal tract include vasoactive intestinal peptide and nitric oxide. ⦁ Relaxation of gastrointestinal smooth muscle occurs following activation of nonadrenergic, noncholinergic (NANC) enteric nerve fibers. ⦁ Acetylcholine, substance P, and dopamine are excitatory neurotransmitters. ⦁ Somatostatin is a paracrine secretory product with multiple effects on gastrointestinal function. Ans. B. Vasoactive intestinal peptide
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Answer2874. #EXPLANATION ⦁ The large bumps at the back of his tongue are circumvallate papillae. These are large circular structures surrounded by moat-like depressions. The lateral surfaces of these papillae contain taste buds. There are also small serous-only salivary glands in these papillae. ⦁ Aphthous ulcers are small, white, or red mouth lesions. ⦁ Candidal colonies appear in thrush, which occurs more commonly in the immunocompromised host or in those taking antibacterial drugs. You are told that the patient is healthy and not taking medications, making this condition unlikely. ⦁ Filiform papillae are the most numerous papillae of the tongue. They are small, elongated cones that create the tongue's rough texture. They do not contain taste buds. ⦁ Fungiform papillae are mushroom-shaped structures scattered among the filiform papillae. They frequently contain taste buds. They are intermediate in size between filiform and circumvallate papillae. Ans. C. Circumvallate papillae
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Answer2873. #EXPLANATION ⦁ A variety of highly regulated protein kinases can cause activation or deactivation of certain key regulatory proteins by covalent modification of specific serine, threonine, or tyrosine hydroxyl residues by phosphorylation. ⦁ For example, skeletal muscle glycogen phosphorylase b is activated by phosphorylation of a single serine residue (serine 14) in each subunit of the dimers composing the enzyme. ⦁ The phosphorylation reaction itself is catalyzed by phosphorylase kinase. Protein phosphatases can quickly reverse such effects. ⦁ Activated muscle glycogen phosphorylase a is deactivated by a specific phosphatase that hydrolyzes the phosphoryl group off of serine 14. ⦁ Whether the phosphorylated or dephosphorylated form of a protein predominates depends on the relative activities of the kinase versus the phosphatase. Ans. B. Kinases
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Answer2871. #EXPLANATION ⦁ Chromosomal abnormalities may involve changes in number (i.e., polyploidy and aneuploidy) or changes in structure (i.e., rearrangements such as translocations, rings, and inversions). ⦁ Extra material (i.e., extra chromatin) seen on chromosome 5 implies recombination of chromo some 5 DNA with that of another chromosome to produce a rearranged chromosome. ⦁ Since this rearranged chromosome 5 takes the place of a normal chromosome 5, there is no change in number of the autosomes (nonsex chromosomes) or sex chromosomes (X and Y chromosomes). ⦁ The question implies that all cells karyotyped from the patient (usually 11 to 25 cells) have the same chromosomal constitution, ruling out mosaicism. ⦁ The patient’s clinical findings are similar to those occurring in trisomy 13, suggesting that the extra material on chromosome 5 is derived from chromosome 13, producing an unbalanced karyotype called dup (13) or partial trisomy 13. Ans. D. Unbalanced rearrangement
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Answer2872. #EXPLANATION ⦁ The strongest stimulator for the release of secretin from cells in the upper small-intestinal mucosa is the contact with acidic Chyme. ⦁ Increased serum secretin levels stimulate water and alkali secretions from the pancreas and the hepatic ducts and inhibit gastrin release. The release of pancreatic enzymes is stimulated by cholecystokinin (choice A). ⦁ The most potent stimulators for the release of cholecystokinin are not acid, but digestion products of fat and protein. Strong stimulators for gastrin secretion (choice B) are vagus nerve excitation, distention of the stomach, and protein digestion products. ⦁ Gastrin then stimulates acid secretion and mucosal growth. The major effect of glucagon (choice C) is to increase blood glucose levels. Hence, it is secreted in response to hypoglycemia and protein digestion products, which are then used for gluconeogenesis. ⦁ VIP indeed stimulates intestinal and pancreatic secretion. However, it acts as neurotransmitter in the enteric nervous system and is mainly released by mechanical and neuronal stimulation. Ans. D. Secretin
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Answer2870. #EXPLANATION ⦁ The oculomotor nerve innervates the levator palpebrae superioris, which elevates the eyelid. This nerve also innervates the inferior oblique muscles, as well as the superior, inferior, and medial rectus muscles. ⦁ The oculomotor nerve also contains preganglionic parasympathetic fibers that synapse, in the ciliary ganglion, on postganglionic parasympathetic nerve fibers that innervate the sphincter pupillae muscle, which constricts the pupil. A lesion of the oculomotor nerve may therefore result in both drooping of the eyelid (ptosis) and dilation of the pupil (mydriasis). ⦁ The cervical sympathetic chain contains preganglionic sympathetic nerve fibers, arising from the upper thoracic spinal cord, which ascend to the cervical sympathetic ganglia. A lesion of these nerves may result in Horner's syndrome, which includes a ptosis and miosis (pupillary constriction) and, often, anhidrosis (lack of sweating). ⦁ The facial nerve innervates the muscles of facial expression, including the orbicularis oculi muscle. A lesion of this nerve may therefore result in the inability to close the eye. ⦁ The superior cervical ganglion contains the cell bodies of postganglionic sympathetic nerves that innervate structures in the head. A lesion of this structure will cause Horner's syndrome. ⦁ The trigeminal nerve provides sensory innervation to much of the head. A lesion of this nerve may interfere with the corneal blink reflex. Ans. C. Oculomotor nerve
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Answer2869. #EXPLANATION ⦁ As the gastric reservoir fills during a meal, mechanoreceptors signal the CNS. When the limits of adaptive relaxation in the reservoir are reached, signals from the stretch receptors in the reservoir’s walls account for the sensations of fullness and satiety. ⦁ Over distention is perceived as discomfort. Adaptive relaxation appears to malfunction in the forms of functional dyspepsia characterized by the symptoms described in this question. ⦁ If adaptive relaxation is compromised (e.g., by an enteric neuropathy), mechanoreceptors are activated at lower distending volumes and the CNS wrongly interprets the signals as if the gastric reservoir were full. ⦁ None of the other choices would be expected to activate mechanosensory signaling of the state of fullness of the gastric reservoir. Ans. A. Malfunction of adaptive relaxation in the gastric reservoir
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Answer2868. #EXPLANATION ⦁ In both smooth and striated muscle, contraction is produced by the cross- bridge cycle in which the cross-bridge on the thick filament binds to the actin molecule on the thin filament. ⦁ In excitation-contraction coupling in striated muscle, calcium initiates contraction by binding to troponin. ⦁ The calcium-activated troponin then acts to remove the tropomyosin-mediated inhibition of the actin-myosin interaction. In excitation-contraction coupling in smooth muscle, calcium initiates contraction by binding to calmodulin. ⦁ The calcium-activated calmodulin then activates the myosin light chain protein kinase (MLCK) enzyme, which phosphorylates the myosin light chains. Actin-myosin interaction follows light-chain phosphorylation. Ans. D. Actin
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Answer2866. #EXPLANATION ⦁ In TGA, the aorta arises from the right ventricle and the pulmonary trunk arises from the left ventricle (choice C). ⦁ This is the reverse of the normal situation and gives rise to the cyanotic condition in the newborn. ⦁ The large arteries arise from the truncus arteriosus in the developing heart and thus could not develop from the atria (choices B), which are formed from the sinus venosus. ⦁ The truncus arteriosus and the sinus venosus are at opposite ends of the heart. ⦁ The ductus arteriosus (choice A) is the vessel that shunts oxygenated blood from the pulmonary trunk to the arch of the aorta in the fetus. It does not give rise to the aorta. Ans. D. Right ventricle
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Answer2867. #EXPLANATION ⦁ The slower cycling rate of the cross-bridges in smooth muscle means that a higher percentage of possible cross-bridges is active at any point in time. ⦁ He more active cross-bridges there are, the greater the force that is generated. Although the relatively slow cycling rate means that it takes longer for the myosin head to attach to the actin filament, it also means that the myosin head remains attached longer, prolonging muscle contraction. ⦁ Because of the slow cross-bridge cycling rate, smooth muscle actually requires less energy to maintain a contraction compared with skeletal muscle. Ans. D. Slower cycling rate of the smooth muscle myosin cross-bridges
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Answer2885. #EXPLANATION GOALS OF JSSK ARE: ⦁ To reduce out –of-pocket expenses related to maternal and new-born care. ⦁ The scheme implemented across the country entitles all pregnant woman delivering in public health institutions to absolutely free and no expense normal delivery (3 days), including caesarean section (7 days). ⦁ Similar entitlements are in place for all sick new-born (first 30 days of life) accessing public health institutions for treatment. ⦁ Free assured transport (ambulance service) from home to health facility, inter-facility transfer in case of referral and drop back is an entitlement Ans. B. JSSK (Janani-Shishu Suraksha Karyakram)
إظهار الكل...
Answer2884. #EXPLANATION ⦁ The few symptoms of the bite include: tightening of the facial muscles in one to two hours of the bite; inability of the bite victim to see or talk, and, if left untreated, the patient may die from respiratory paralysis within four to five hours. ⦁ A clinical toxicology study gives an untreated mortality rate of 70-80% Ans. C. Krait bite
إظهار الكل...
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Answer2883. #EXPLANATION ⦁ Indinavir is a protease inhibitor AND olanzapine is an atypical antipsychotic, both cause metabolic syndrome like hyperlipidemia and central obesity Ans. D. Both B and C
إظهار الكل...
Answer2881. #EXPLANATION ⦁ Hyponatremia and inability to form dilute urine in the fully hydrated condition with concomitant lung cancer points to suspicion of SIADH. ⦁ Antagonists of ADH are used to treat SIADH. Tolvaptan - ⦁ It is a direct ADH receptor antagonist. ⦁ It is used for the correction of water retention and hyponatremia occurring in syndrome of inappropriate ADH secretion (SIADH) as well as in advanced CHF. ⦁ In clinical trials on CHF patients with hyponatremia - Tolvaptan has afforded short-term improvement by increasing water excretion, restoring serum Na· and relieving dyspnoea. Ans. D. Tolvaptan
إظهار الكل...
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Answer2882. #EXPLANATION ⦁ Epidemic typhus (classical typhus fever, or louse-borne typhus) has disappeared from most areas of the world but might reappear in conditions of famine, war, or other disasters. There are small areas where it is endemic. ⦁ The responsible organism, a rickettsia, is conveyed from case to case by the human body louse, P. humanus corporis. Malaria, in its various forms (Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae), is spread from human to human by females of the various Anopheles group of mosquitoes. ⦁ Dengue fever has a worldwide distribution in tropical and subtropical areas. In addition to producing the classical fever with severe myalgia (breakbone fever), it can also cause a hemorrhagic fever. ⦁ The causative agent, a group B arbovirus with four distinct serogroups, is virus-conveyed from case to case by the A. aegypti mosquito. Colorado tick fever occurs mainly in mountainous areas of the United States within the range of its vector, D. andersoni. ⦁ The highest incidence is in May and June. Several hundred cases are recorded annually, but it is likely that the actual incidence is much higher. Avoidance of tick bites is the principal control measure. ⦁ Yellow fever, the prototypical viral hemorrhagic fever, is African in origin but has spread to and remains endemic in equatorial regions of Central and South America. The vector, A. aegypti, has also spread worldwide, but surprisingly, cases have not been reported in India and Southeast Asia. ⦁ The illness varies in severity from a mild, nonspecific fever to a more severe condition with hemorrhagic, hepatic, and renal manifestations. Ans. C. Pediculus humanus corporis
إظهار الكل...
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Q2885. A recent delivered women with a 15 day old child suffering from cough, sneezing and fever needs help. She has no money for transportation to nearby hospital. Which of the following national programme can help this woman?Anonymous voting
  • a. IMNCI
  • b. JSSK
  • c. CSSM
  • d. ICDS
0 votes
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Q2884. A 16 year old girl, otherwise healthy, sleeping on the floor suddenly develops nausea, vomiting, abdominal pain, quadriplegia at night. Diagnosis is:Anonymous voting
  • A. Guillain Barre syndrome
  • B. Poliomyelitis
  • C. Krait bite
  • D. Periodic paralysis
0 votes
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Q2883. A HIV patient with schizophrenia is on indinavir, zidovudine, lamivudine and olanzapine. He developed hyperglycemia, hyperlipidemia and central obesity. Which of the following drugs are responsible for above adverse drug reaction?Anonymous voting
  • a. Lamivudine
  • b. Indinavir
  • c. Olanzapine
  • d. Both B and C
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Q2881. A 56-year-old lady, who is a known case of lung cancer, has low serum osmolarity and low serum sodium. She has normal water intake. Which of the following drugs is useful for this patient?Anonymous voting
  • a) Acetazolamide
  • b) Hydrochlorothiazide
  • c) Triamterene
  • d) Tolvaptan
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Q2882. Which Arthropod vector is responsible for Epidemic typhus transmission?Anonymous voting
  • (A) A. aegypti
  • (B) Anopheles species
  • (C) Pediculus humanus corporis
  • (D) Dermacentor andersoni
0 votes
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