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Permanent Nursing Officer Vacancy in BHU

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Permanent Nursing Officer Vacancy in BHU and AIIMS

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Permanent Nursing Officer Vacancy in BHU and AIIMS

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AIIMS NORCET Vacancy Announce....

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Big Update...

AIIMS NORCET Vacancy Announce....

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*Complete List of Antidotes* ### *1. Drug Overdose & Poisoning Antidotes* Poison/Drug Antidote Key Points Paracetamol/Acetaminophen N-acetylcysteine (NAC) Most effective within 8-10 hrs. Oral or IV Opioids - Morphine, Heroin Naloxone Reverses respiratory depression. Short half-life, may need repeat dose Benzodiazepines Flumazenil Use cautiously - can precipitate seizures in mixed overdose Digoxin Digoxin Immune Fab (Digibind) For life-threatening toxicity, arrhythmias, K+ >5.5 Beta-blockers Glucagon Increases cAMP. Atropine + IV fluids also used Calcium Channel Blockers Calcium gluconate + Glucagon + Insulin + Glucose "High dose insulin euglycemic therapy" Warfarin Vitamin K, FFP, Prothrombin Complex Vitamin K for mild, FFP for bleeding Heparin Protamine Sulfate 1mg protamine neutralizes ~100 units heparin Iron Deferoxamine Chelates iron. Red urine = therapeutic Lead, Mercury, Arsenic BAL (Dimercaprol) Chelating agent. "British Anti-Lewisite" Lead, Iron Deferoxamine Also used for iron Lead, Arsenic, Mercury DMSA (Succimer) Oral chelator, safer for children Lead, Copper D-Penicillamine Oral chelator Copper, Gold, Arsenic Trientine Alternative to penicillamine Methanol, Ethylene Glycol Fomepizole or Ethanol Blocks alcohol dehydrogenase Cyanide Hydroxocobalamin, Sodium Nitrite + Sodium Thiosulfate "Cyanide antidote kit" Organophosphates Atropine + Pralidoxime (2-PAM) Atropine for muscarinic, 2-PAM for nicotinic Carbamates Atropine only No 2-PAM needed Radioactive Iodine Potassium Iodide (KI) Blocks thyroid uptake Radioactive Cesium, Thallium Prussian Blue Enhances fecal excretion Tricyclic Antidepressants Sodium Bicarbonate For QRS widening, arrhythmias Isoniazid (INH) Pyridoxine (Vitamin B6) Prevents seizures Methotrexate Leucovorin (Folinic Acid) "Rescue therapy" Sulfonylureas Octreotide + Glucose Prevents hypoglycemia Methylene Blue For Nitrite-induced Methemoglobinemia 1-2 mg/kg IV ### *2. Snake Bite & Animal Bites* Bite Antidote Snake bite - Indian 4 venomous Polyvalent Anti-Snake Venom (ASV) Rabies Rabies Immunoglobulin + Rabies Vaccine ### *3. Other Important Antidotes* Condition Antidote Magnesium Sulfate Toxicity Calcium Gluconate Local Anesthetic Toxicity Intralipid 20% Nitroglycerin Headache No specific antidote - supportive Steroid Overdose No antidote - taper slowly ### *4. NORCET High-Yield MCQs* *Q1.* Antidote for Paracetamol poisoning? A) Naloxone B) N-acetylcysteine C) Flumazenil D) Protamine *Ans: B* *Q2.* Antidote for Organophosphorus poisoning? A) Atropine + Pralidoxime B) Naloxone + Flumazenil C) Vitamin K + FFP D) Deferoxamine *Ans: A* *Q3.* Protamine sulfate is used for: A) Warfarin toxicity B) Heparin toxicity C) Digoxin toxicity D) Iron toxicity *Ans: B* *Q4.* BAL is antidote for: A) Lead, Arsenic, Mercury B) Iron, Lead C) Methanol D) Cyanide *Ans: A* *Q5.* Hydroxocobalamin is used in: A) Cyanide poisoning B) CO poisoning C) Methemoglobinemia D) Benzodiazepine overdose *Ans: A* ### *5. Memory Tricks* 1. *"PAN"*: *P*aracetamol = *N*AC 2. *"NO"*: *N*aloxone for *O*pioids 3. *"2 P's"*: *P*ralidoxime + *P*hosphates = OP poisoning 4. *"W.H.A.L.E."*: *W*arfarin = *V*itamin K, *H*eparin = *P*rotamine, *L*ead = *B*AL/DMSA, *E*thylene glycol = *F*omepizole ### *6. Nursing Responsibilities During Antidote Administration* 1. *Check vitals* before, during, after 2. *Monitor for anaphylaxis* - especially with ASV, Digibind 3. *IV site care* - many antidotes are vesicants 4. *Document* time, dose, route, patient response 5. *Supportive care* - O2, airway, IV fluids