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شرح مادة الصيدلة السريرية clinical pharmacology 🧑🏻⚕️ معرف التلي: mohammedsalim10 Instagram: _a1mh
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patients with refectory schizophrenia. Mood stabilizers may improve labile affect and agitation:
a- Valproic acid
b- Clozapine
c- Sertraline
d- loxapine
e- Aripiprazole
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Which of the following is an example of a positive symptom in
schizophrenia?
a- Poverty of speech
b- Blunted affect
c- Flattened affect
d- Hallucinations
e- Lack of initiative
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A patient with first episode schizophrenia was treated by usual therapeutic dose of
risperidone. After 2 weeks of treatment‚ the patient achieved a partial response. Knowing
that the patient was adherent to therapy and well tolerating it. Which treatment option is
the most reasonable for this patient?
a- Increase the dose of risperidone with close monitoring
b- Shift to clozapine
c- Add haloperidol to current therapy
d- Add clozapine to current therapy
e- None of the above
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A patient with resistant schizophrenia was prescribed clozapine. Why clozapine should
be titrated slowly (slower than other antipsychotics)?
a- Because of its hyperglycemic effect
b- Because of its orthostatic hypotension effect
c- Because of its extra-pyramidal side effects
d- Because of its ability to induce weight gain
e- Because of its seizure inducing effect
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Q.J. is 37 years old lactating mother with schizophrenia. Which one of the following drugs has the highest risk on the infant?
a- Risperidone
b- Haloperidol
c- Olanzapine
d- Aripiprazole
e- Quetiapine
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Which antipsychotic medications are suggested as preferred first-line options for Nael?
a- Any antipsychotic medication can be used as a first-line option.
b- Long-acting injectable antipsychotics are preferred for all patients.
c- Pregabalin
d- Chlorpromazine or thioridazine
e- Aripiprazole‚ risperidone‚ or ziprasidone
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A patient diagnosed with schizophrenia suffering from myoglobinuria‚ leukocytosis and
high levels of serum creatine kinase‚ AST‚ ALT and LDH. All the following therapeutic options can be used to manage this condition EXCEPT:
a- Dantrolene
b- Bromocriptine (D2 agonist)
c- Amantadine
d- High potency FGA
e- lowest effective dose of SGA
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Adult patients with schizophrenia have a high prevalence of type 2 diabetes‚ which antipsychotic is more likely to worsen this condition?
a- Aripiprazole
b- Olanzapine
c- Asenapine
d- Iloperidone
e- Lumateperone
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Which of the following medications is considered a second-generation (atypical)
antipsychotic with a high affinity for both serotonin (5-HT2A) and dopamine (D2) receptors‚
and is often preferred for its lower risk of extrapyramidal side effects?
a- Haloperidol
b- thioridazine
c- Risperidone
d- Chlorpromazine
e- Sulpiride
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Which of the following statements about the use of antipsychotics in pregnancy is
accurate?
a- All antipsychotics are completely safe to use throughout pregnancy
b- Haloperidol has been the most studied first-generation antipsychotic in pregnancy
c- Second-generation antipsychotics significantly increase the risk of congenital malformations
d- Antipsychotics should never be used during pregnancy under any circumstance
e- In utero exposure to antipsychotics has no effect on neonatal outcomes
